Titration of RAS alters senescent state and influences tumour initiation.
Chan ASL, Zhu H, Narita M, Cassidy LD, Young ARJ, Bermejo-Rodriguez C, Janowska AT, Chen HC, Gough S, Oshimori N, Zender L, Aitken SJ, Hoare M, Narita M
Nature. 2024 Sep;633(8030):678-685. doi: 10.1038/s41586-024-07797-z. Epub 2024 Aug 7.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 236072 | pT/CAGGS-mVenus-P2A-NRASG12V | Sleeping Beauty transposon plasmid for hydrodynamic tail vein injection (HDTVi) into mice. Caggs promotor driven expression of mVenus and mutant NRAS (NRASG12V). |
| 236073 | pT/PGK-mVenus-P2A-NRASG12V | Sleeping Beauty transposon plasmid for hydrodynamic tail vein injection (HDTVi) into mice. Pgk promotor driven expression of mVenus and mutant NRAS (NRASG12V). |
| 236074 | pT/UBC-mVenus-P2A-NRASG12V | Sleeping Beauty transposon plasmid for hydrodynamic tail vein injection (HDTVi) into mice. Ubc promotor driven expression of mVenus and mutant NRAS (NRASG12V). |
| 236076 | pT/CAGGS-NRASG12V-IRES-mVenus | Sleeping Beauty transposon plasmid for hydrodynamic tail vein injection (HDTVi) into mice. Caggs promotor driven expression of mVenus and mutant NRAS (NRASG12V). |
| 236077 | pT/CAGGS-NRASG12V/D38A-IRES-mVenus | Sleeping Beauty transposon plasmid for hydrodynamic tail vein injection (HDTVi) into mice. Caggs promotor driven expression of mVenus and a double mutant NRAS (NRASG12VD38A). |
| 236078 | pPGK-SB13 | SB13 transposase, for use with Sleeping Beauty transponson plasmids |