Clec12a is required for the pathogenesis of NUP98::NSD1 AML.
Mohanty S, Charles Cano F, Gabdoulline R, Lai CK, Othman B, Sudarsanam H, Eder T, Grebien F, Lipka DB, Henschler R, Heuser M
Blood Adv. 2025 May 7:bloodadvances.2024015739. doi: 10.1182/bloodadvances.2024015739.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 236201 | MSCV-IRES-NUP98::NSD1-GFP | Expresses NUP98::NSD1 fusion protein in mammalian cells |
| 236202 | MSCV-IRES-NRASG12D-BFP | Expresses NRASG12D in mammalian cells |
| 236203 | sgRNA Clec12a (CT6) | lentiviral expression of Cas9 and encodes CT6 sgRNA for CLEC12A deletion |
| 236204 | sgRNA Clec12a (CT44) | lentiviral expression of Cas9 and encodes CT44 sgRNA for CLEC12A deletion |
| 236205 | sgRNA Clec12a (CT47) | lentiviral expression of Cas9 and encodes CT47 sgRNA for CLEC12A deletion |