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AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy.

Lin J, Lin Y, Liu N, Cao W, Zhang J, Wen S, Zhang Y, Liao W, Hong Z, Lin Y, Liu Q, Liu H, Li Q, Chen B, Li M, Luo Z, Yang L, Yang Y, Zheng SH, Wang Y, Chu H, Hu Y, Qin Y, Luo BX, Tian S, Chen Y, Yan T, Yang L, Wang H, Liu T, Jiang Y, Lu Z
Cell. 2026 Feb 5;189(3):969-986.e17. doi: 10.1016/j.cell.2025.12.039. Epub 2026 Jan 27. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
236644pAAVLINK-EF1alpha-5' NUP1555' AAVLINK plasmid for NUP155 expression
236645pAAVLINKv1-pCALM1-Cre-3' NUP1553' AAVLINK plasmid for NUP155 expression
236646pAAVLINK-EF1alpha-5' POGZ5' AAVLINK plasmid for POGZ expression
236647pAAVLINKv1-pCALM1-Cre-3' POGZ3' AAVLINK plasmid for POGZ expression
236648pAAVLINKv1-EF1alpha-5' KDM5B5' AAVLINK plasmid for KDM5B expression
236649pAAVLINKv1-pCALM1-Cre-3' KDM5B3' AAVLINK plasmid for KDM5B expression
236650pAAVLINK-EF1alpha-5' DIP2A5' AAVLINK plasmid for DIP2A expression
236651pAAVLINKv1-pCALM1-Cre-3' DIP2A3' AAVLINK plasmid for KDIP2A expression
236652pAAVLINK-EF1alpha-5' SMARCA25' AAVLINK plasmid for SMARCA2 expression
236653pAAVLINKv1-pCALM1-Cre-3' SMARCA25' AAVLINK plasmid for SMARCA2 expression
236658pAAVLINK-EF1alpha-5' CHD25' AAVLINK plasmid for CHD2 expression
236659pAAVLINKv1-pCALM1-Cre-3' CHD23' AAVLINK plasmid for CHD2 expression
236660pAAVLINK-EF1alpha-5' KDM2B5' AAVLINK plasmid for KDM2B expression
236661pAAVLINKv1-pCALM1-Cre-3' KDM2B3' AAVLINK plasmid for KDM2B expression
236668pAAVLINK-EF1alpha-5' NEXMIF5' AAVLINK plasmid for NEXMIF expression
236669pAAVLINKv1-pCALM1-Cre-3' NEXMIF3' AAVLINK plasmid for NEXMIF expression
236670pAAVLINK-EF1alpha-5' KDM5C5' AAVLINK plasmid for KDM5C expression
236671pAAVLINKv1-pCALM1-Cre-3' KDM5C3' AAVLINK plasmid for KDM5C expression
236672pAAVLINK-EF1alpha-5' AHDC15' AAVLINK plasmid for AHDC1 expression
236673pAAVLINKv1-pCALM1-Cre-3' AHDC13' AAVLINK plasmid for AHDC1 expression
236676pAAVLINK-EF1alpha-5' PRR125' AAVLINK plasmid for PRR12 expression
236677pAAVLINKv1-pCALM1-Cre-3' PRR123' AAVLINK plasmid for PRR12 expression
236678pAAVLINK-EF1alpha-5' UBN25' AAVLINK plasmid for UBN2 expression
236679pAAVLINKv1-pCALM1-Cre-3' UBN23' AAVLINK plasmid for UBN2 expression
236680pAAVLINK-EF1alpha-5' KANK15' AAVLINK plasmid for KANK1 expression
236681pAAVLINKv1-pCALM1-Cre-3' KANK13' AAVLINK plasmid for KANK1 expression
236682pAAVLINK-EF1alpha-5' BRD45' AAVLINK plasmid for BRD4 expression
236683pAAVLINKv1-pCALM1-Cre-3' BRD43' AAVLINK plasmid for BRD4 expression
236686pAAVLINK-EF1alpha-5' ROBO25' AAVLINK plasmid for ROBO2 expression
236687pAAVLINKv1-pCALM1-Cre-3' ROBO23' AAVLINK plasmid for ROBO2 expression
236688pAAVLINK-EF1alpha-5' KDM6A5' AAVLINK plasmid for KDM6A expression
236689pAAVLINKv1-pCALM1-Cre-3' KDM6A3' AAVLINK plasmid for KDM6A expression
236690pAAVLINK-EF1alpha-5' NINL5' AAVLINK plasmid for NINL expression
236691pAAVLINKv1-pCALM1-Cre-3' NINL3' AAVLINK plasmid for NINL expression
236696pAAVLINK-EF1alpha-5' YTHDC25' AAVLINK plasmid for YTHDC2 expression
236697pAAVLINKv1-pCALM1-Cre-3' YTHDC23' AAVLINK plasmid for YTHDC2 expression
236700pAAVLINK-EF1alpha-5' NEO15' AAVLINK plasmid for NEO1 expression
236701pAAVLINKv1-pCALM1-Cre-3' NEO13' AAVLINK plasmid for NEO1 expression
236704pAAVLINK-EF1alpha-5' IQGAP35' AAVLINK plasmid for IQGAP3 expression
236705pAAVLINKv1-pCALM1-Cre-3' IQGAP33' AAVLINK plasmid for IQGAP3 expression
236706pAAVLINK-EF1alpha-5' PHRF15' AAVLINK plasmid for PHRF1 expression
236707pAAVLINKv1-pCALM1-Cre-3' PHRF13' AAVLINK plasmid for PHRF1 expression
236708pAAVLINK-EF1alpha-5' PREX15' AAVLINK plasmid for PREX1 expression
236709pAAVLINKv1-pCALM1-Cre-3' PREX13' AAVLINK plasmid for PREX1 expression
236710pAAVLINK-EF1alpha-5' KDM5A5' AAVLINK plasmid for KDM5A expression
236711pAAVLINKv1-pCALM1-Cre-3' KDM5A3' AAVLINK plasmid for KDM5A expression
236714pAAVLINK-EF1alpha-5' CDC42BPB5' AAVLINK plasmid for CDC42BPB expression
236715pAAVLINKv1-pCALM1-Cre-3' CDC42BPB3' AAVLINK plasmid for CDC42BPB expression
236716pAAVLINK-EF1alpha-5' ITSN15' AAVLINK plasmid for ITSN1 expression
236717pAAVLINKv1-pCALM1-Cre-3' ITSN13' AAVLINK plasmid for ITSN1 expression
244254pAAVLINK-EF1alpha-5'-GRIN2B5' AAVLINK plasmid for GRIN2B expression
244255pAAVLINKv1-pCALM1-Cre-3'-GRIN2B-FLAG3' AAVLINK plasmid for GRIN2B expression
244256pAAVLINK-EF1alpha-HA-5'-IQSEC25' AAVLINK plasmid for IQSEC2 expression
244257pAAVLINKv1-pCALM1-Cre-3'-IQSEC2-FLAG3' AAVLINK plasmid for IQSEC2 expression
244258pAAVLINK-EF1alpha-HA-5'-RALGAPB5' AAVLINK plasmid for RALGAPB expression
244259pAAVLINKv1-pCALM1-Cre-3'-RALGAPB-FLAG3' AAVLINK plasmid for RALGAPB expression
244260pAAVLINK-EF1alpha-HA-5'-MBD55' AAVLINK plasmid for MBD5 expression
244261pAAVLINKv1-pCALM1-Cre-3'-MBD5-FLAG3' AAVLINK plasmid for MBD5 expression
244262pAAVLINK-EF1alpha-HA-5'-RERE5' AAVLINK plasmid for RERE expression
244263pAAVLINKv1-pCALM1-Cre-3'-RERE-FLAG3' AAVLINK plasmid for RERE expression
244264pAAVLINK-EF1alpha-HA-5'-SYNGAP15' AAVLINK plasmid for SYNGAP1 expression
244265pAAVLINKv1-pCALM1-Cre-3'-SYNGAP1-FLAG3' AAVLINK plasmid for SYNGAP1 expression
244266pAAVLINK-EF1alpha-HA-5'-SETBP15' AAVLINK plasmid for SETBP1 expression
244267pAAVLINKv1-pCALM1-Cre-3'-SETBP1-FLAG3' AAVLINK plasmid for SETBP1 expression
244268pAAVLINK-EF1alpha-HA-5'-KDM6B5' AAVLINK plasmid for KDM6B expression
244269pAAVLINKv1-pCALM1-Cre-3'-KDM6B-FLAG3' AAVLINK plasmid for KDM6B expression
244270pAAVLINK-EF1alpha-HA-5'-SMARCA45' AAVLINK plasmid for SMARCA4 expression
244271pAAVLINKv1-pCALM1-Cre-3'-SMARCA4-FLAG3' AAVLINK plasmid for SMARCA4 expression
244272pAAVLINK-EF1alpha-HA-5'-SETD1A5' AAVLINK plasmid for SETD1A expression
244273pAAVLINKv1-pCALM1-Cre-3'-SETD1A-FLAG3' AAVLINK plasmid for SETD1A expression
244274pAAVLINK-EF1alpha-5'-NRXN25' AAVLINK plasmid for NRXN2 expression
244275pAAVLINKv1-pCALM1-Cre-3'-NRXN2-FLAG3' AAVLINK plasmid for NRXN2 expression
244276pAAVLINK-EF1alpha-HA-5'-KDM3B5' AAVLINK plasmid for KDM3B expression
244277pAAVLINKv1-pCALM1-Cre-3'-KDM3B-FLAG3' AAVLINK plasmid for KDM3B expression
244278pAAVLINK-EF1alpha-HA-5'-PHIP5' AAVLINK plasmid for PHIP expression
244280pAAVLINK-EF1alpha-HA-5'-SHANK25' AAVLINK plasmid for SHANK2 expression
244281pAAVLINKv1-pCALM1-Cre-3'-SHANK2-FLAG3' AAVLINK plasmid for SHANK2 expression
244283pAAVLINKv1-pCALM1-Cre-3'-RAI1-FLAG3' AAVLINK plasmid for RAI1 expression
244284pAAVLINK-EF1alpha-HA-5'-TCF205' AAVLINK plasmid for TCF20 expression
244285pAAVLINKv1-pCALM1-Cre-3'-TCF20-FLAG3' AAVLINK plasmid for TCF20 expression
244287pAAVLINKv1-pCALM1-Cre-3'-SCN8A-FLAG3' AAVLINK plasmid for SCN8A expression
244288pAAVLINK-EF1alpha-HA-5'-TANC25' AAVLINK plasmid for TANC2 expression
244289pAAVLINKv1-pCALM1-Cre-3'-TANC2-FLAG3' AAVLINK plasmid for TANC2 expression
244290pAAVLINK-EF1alpha-HA-5'-KIAA02325' AAVLINK plasmid for KIAA0232 expression
244292pAAVLINK-EFS-HA-5'-PRR14L5' AAVLINK plasmid for PRR14L expression
244293pAAVLINKv1-pCALM1-Cre-3'-PRR14L-FLAG3' AAVLINK plasmid for PRR14L expression
244294pAAVLINK-EFS-HA-5'-MED13L5' AAVLINK plasmid for MED13L expression
244295pAAVLINKv1-pCALM1-Cre-3'-MED13L-FLAG3' AAVLINK plasmid for MED13L expression
244296pAAVLINK-EFS-HA-5'-CACNA1C5' AAVLINK plasmid for CACNA1C expression
244297pAAVLINKv1-pCALM1-Cre-3'-CACNA1C-FLAG3' AAVLINK plasmid for CACNA1C expression
244298pAAVLINK-EF1alpha-HA-5'-SETD55' AAVLINK plasmid for SETD5 expression
244299pAAVLINKv1-pCALM1-Cre-3'-SETD5-FLAG3' AAVLINK plasmid for SETD5 expression
244300pAAVLINK-EF1alpha-5'-GRIN2A5' AAVLINK plasmid for GRIN2A expression
244301pAAVLINKv1-pCALM1-Cre-3'-GRIN2A-FLAG3' AAVLINK plasmid for GRIN2A expression
244302pAAVLINK-EF1alpha-5'-NRXN15' AAVLINK plasmid for NRXN1 expression
244303pAAVLINKv1-pCALM1-Cre-3'-NRXN1-FLAG3' AAVLINK plasmid for NRXN1 expression
244304pAAVLINK-EF1alpha-HA-5'-ZMYM25' AAVLINK plasmid for ZMYM2 expression
244305pAAVLINKv1-pCALM1-Cre-3'-ZMYM2-FLAG3' AAVLINK plasmid for ZMYM2 expression
244306pAAVLINK-EF1alpha-HA-5'-ERBIN5' AAVLINK plasmid for ERBIN expression
244307pAAVLINKv1-pCALM1-Cre-3'-ERBIN-FLAG3' AAVLINK plasmid for ERBIN expression
244308pAAVLINK-EF1alpha-HA-5'-YEATS25' AAVLINK plasmid for YEATS2 expression
244310pAAVLINK-EF1alpha-5'-ASTN25' AAVLINK plasmid for ASTN2 expression
244311pAAVLINKv1-pCALM1-Cre-3'-ASTN2-HA3' AAVLINK plasmid for ASTN2 expression
244312pAAVLINK-EF1alpha-5'-PCDH11X5' AAVLINK plasmid for PCDH11X expression
244313pAAVLINKv1-pCALM1-Cre-3'-PCDH11X-HA3' AAVLINK plasmid for PCDH11X expression
244314pAAVLINK-EF1alpha-5'-PXDN5' AAVLINK plasmid for PXDN expression
244315pAAVLINKv1-pCALM1-Cre-3'-PXDN-FLAG3' AAVLINK plasmid for PXDN expression
244316pAAVLINK-EF1alpha-HA-5'-CECR25' AAVLINK plasmid for CECR2 expression
244317pAAVLINKv1-pCALM1-Cre-3'-CECR2-FLAG3' AAVLINK plasmid for CECR2 expression
244318pAAVLINK-EF1alpha-HA-5'-CUX25' AAVLINK plasmid for CUX2 expression
244319pAAVLINKv1-pCALM1-Cre-3'-CUX2-FLAG3' AAVLINK plasmid for CUX2 expression
244320pAAVLINK-EF1alpha-HA-5'-ATP10A5' AAVLINK plasmid for ATP10A expression
244321pAAVLINKv1-pCALM1-Cre-3'-ATP10A-FLAG3' AAVLINK plasmid for ATP10A expression
244322pAAVLINK-EF1alpha-HA-5'-ARHGAP55' AAVLINK plasmid for ARHGAP5 expression
244323pAAVLINKv1-pCALM1-Cre-3'-ARHGAP5-FLAG3' AAVLINK plasmid for ARHGAP5 expression
244324pAAVLINK-EF1alpha-HA-5'-CUX15' AAVLINK plasmid for CUX1 expression
244325pAAVLINKv1-pCALM1-Cre-3'-CUX1-FLAG3' AAVLINK plasmid for CUX1 expression
244326pAAVLINK-EF1alpha-HA-5'-CLASP15' AAVLINK plasmid for CLASP1 expression
244327pAAVLINKv1-pCALM1-Cre-3'-CLASP1-FLAG3' AAVLINK plasmid for CLASP1 expression
244328pAAVLINK-EF1alpha-HA-5'-DIP2C5' AAVLINK plasmid for DIP2C expression
244329pAAVLINKv1-pCALM1-Cre-3'-DIP2C-FLAG3' AAVLINK plasmid for DIP2C expression
244330pAAVLINK-EF1alpha-HA-5'-HECW25' AAVLINK plasmid for HECW2 expression
244332pAAVLINK-EF1alpha-HA-5'-TRPM15' AAVLINK plasmid for TRPM1 expression
244333pAAVLINKv1-pCALM1-Cre-3'-TRPM1-FLAG3' AAVLINK plasmid for TRPM1 expression
244334pAAVLINK-EF1alpha-HA-5'-TOP2B5' AAVLINK plasmid for TOP2B expression
244335pAAVLINKv1-pCALM1-Cre-3'-TOP2B-FLAG3' AAVLINK plasmid for TOP2B expression
244336pAAVLINK-EF1alpha-HA-5'-CLTCL15' AAVLINK plasmid for CLTCL1 expression
244337pAAVLINKv1-pCALM1-Cre-3'-CLTCL1-FLAG3' AAVLINK plasmid for CLTCL1 expression
244338pAAVLINK-EF1alpha-HA-5'-KIF145' AAVLINK plasmid for KIF14 expression
244339pAAVLINKv1-pCALM1-Cre-3'-KIF14-FLAG3' AAVLINK plasmid for KIF14 expression
244340pAAVLINK-EF1alpha-HA-5'-TNRC6C5' AAVLINK plasmid for TNRC6C expression
244341pAAVLINKv1-pCALM1-Cre-3'-TNRC6C-FLAG3' AAVLINK plasmid for TNRC6C expression
244342pAAVLINK-EFS-HA-5'-KIF1A5' AAVLINK plasmid for KIF1A expression
244343pAAVLINKv1-pCALM1-Cre-3'-KIF1A-FLAG3' AAVLINK plasmid for KIF1A expression
244344pAAVLINK-EF1alpha-HA-5'-UNC13A5' AAVLINK plasmid for UNC13A expression
244345pAAVLINKv1-pCALM1-Cre-3'-UNC13A-FLAG3' AAVLINK plasmid for UNC13A expression
244346pAAVLINK-EF1alpha-HA-5'-CHD15' AAVLINK plasmid for CHD1 expression
244347pAAVLINKv1-pCALM1-Cre-3'-CHD1-FLAG3' AAVLINK plasmid for CHD1 expression
244348pAAVLINK-EF1alpha-HA-5'-MYO5C5' AAVLINK plasmid for MYO5C expression
244349pAAVLINKv1-pCALM1-Cre-3'-MYO5C-FLAG3' AAVLINK plasmid for MYO5C expression

Antibodies from Article