Antibody-lectin chimeras for glyco-immune checkpoint blockade.
Stark JC, Gray MA, Ibarlucea-Benitez I, Lustig M, Bond A, Cho B, Govil I, Luu T, Priestley MJ, Veth TS, Errington WJ, Bruncsics B, Ribi MK, Williams LA, Sarkar CA, Wisnovsky S, Riley NM, Morrissey MA, Valerius T, Ravetch JV, Bertozzi CR.
Nat Biotechnol 2025
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 237364 | pTCB-trasHCknob6xHis | pTwist CMV BetaGlobin encoding trastuzumab heavy chain with knob Fc and 6xHis tag |
| 237365 | pTCB-trasLC | pTwist CMV BetaGlobin encoding trastuzumab light chain |
| 237366 | TCB-Sig7FcLALAPGholeHA | pTwist CMV BetaGlobin encoding Siglec-7-Fc with LALA P329G hole Fc and HA tag |
| 237367 | pTCB-Sig9FcholeHA | pTwist CMV BetaGlobin encoding Siglec-9-Fc with hole Fc and HA tag |
| 237368 | pTCB-Sig7R124AFcholeHA | pTwist CMV BetaGlobin encoding Siglec-7-Fc R124A mutant with hole Fc and HA tag |
| 237369 | pTCB-Sig9R120AFcholeHA | pTwist CMV BetaGlobin encoding Siglec-9-Fc R120A mutant with hole Fc and HA tag |
| 237370 | pTCB-Sig10FcholeHA | pTwist CMV BetaGlobin encoding Siglec-10-Fc with hole Fc and HA tag |
| 237371 | pTCB-rituxHCknob6xHis | pTwist CMV BetaGlobin encoding rituximab heavy chain with knob Fc and 6xHis tag |
| 237372 | pTCB-rituxLC | pTwist CMV BetaGlobin encoding rituximab light chain |
| 237373 | pTCB-cetuxHCknob6xHis | pTwist CMV BetaGlobin encoding cetuximab heavy chain with knob Fc and 6xHis tag |
| 237374 | pTCB-cetuxLC | pTwist CMV BetaGlobin encoding cetuximab light chain |
| 237375 | pTCB-magroHCLALAPGknob6xHis | pTwist CMV BetaGlobin encoding magrolimab heavy chain with LALA P329G knob Fc and 6xHis tag |
| 237376 | pTCB-magroLC | pTwist CMV BetaGlobin encoding magrolimab light chain |
| 237377 | pTCB-nivoHCLALAPGknobHA | pTwist CMV BetaGlobin encoding nivolumab heavy chain with LALA P329G knob Fc and HA tag |
| 237378 | pTCB-nivoLC | pTwist CMV BetaGlobin encoding nivolumab light chain |
| 237379 | pTCB-pembroHCLALAPGknobHA | pTwist CMV BetaGlobin encoding pembrolizumab heavy chain with LALA P329G knob Fc and HA tag |
| 237380 | pTCB-pembroLC | pTwist CMV BetaGlobin encoding pembrolizumab light chain |
| 237381 | pTCB-Gal9NFcLALAPGhole6xHis | pTwist CMV BetaGlobin encoding Galectin-9 N terminal carbohydrate binding domain-Fc fusion with LALA P329G hole Fc and 6xHis tag |
| 237382 | pTCB-Sig7FcholeHA | pTwist CMV BetaGlobin encoding Siglec-7-Fc with hole Fc and HA tag |
| 237383 | pTCB-avelHCknob6xHis | pTwist CMV BetaGlobin encoding avelumab heavy chain with knob Fc and 6xHis tag |
| 237384 | pTCB-avelLC | pTwist CMV BetaGlobin encoding avelumab light chain |