Structural basis for the dynamic regulation of mTORC1 by amino acids.
Valenstein ML, Wranik M, Lalgudi PV, Linde-Garelli KY, Choi Y, Chivukula RR, Sabatini DM, Rogala KB
Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09428-7.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 237416 | FLAG-sc-WDR59-SEC13 | Transient expression of N-terminally FLAG-tagged human WDR59-SEC13 "single chain" in the GATOR2 complex |
| 237417 | sc-MIOS-SEH1L | Transient expression of human MIOS-SEH1L "single chain" in the GATOR2 complex |
| 237418 | sc-WDR24-SEH1L | Transient expression of human WDR24-SEH1L "single chain" in the GATOR2 complex |
| 237419 | CASTOR1-HA (D304A) | Transient expression of C-terminally HA-tagged human CASTOR1 (D304A mutant) |
| 237420 | HA-Sestrin2 (E451Q) | Transient expression of N-terminally HA-tagged human Sestrin2 (E451Q) |