KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.
Michmerhuizen NL, Heikamp EB, Iacobucci I, Umeda M, Arthur B, Mishra V, Park CS, Di Giacomo D, Hiltenbrand R, Gao Q, Radko-Juettner S, Lott J, Martucci C, Subramanyam V, Hatton C, Wenge DV, Baviskar P, Portola P, Claquin A, Chandra B, Baggett DW, Khalighifar A, Huang H, Zhou P, Long L, Shi H, Sun Y, Papachristou EK, Sekhar Reddy Chilamakuri C, de Luna Vitorino FN, Gongora JM, Wu H, Pounds SB, Janke LJ, Kentsis A, D'Santos CS, Garcia BA, Kriwacki RW, Chi H, Klco JM, Armstrong SA, Mullighan CG
Cancer Discov. 2025 Jun 19. doi: 10.1158/2159-8290.CD-24-1772.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 237481 | CL20_MSCV-NUP98-ires-GFP | Express NUP98 in bicistronic retroviral vector |
| 237482 | CCLMPC_HA-NUP98 | Express HA-tagged NUP98 in dual promoter lentiviral vector |
| 237483 | CL20_MSCV-NUP98::NSD1-ires-GFP | Express NUP98::NSD1 in bicistronic retroviral vector |
| 237484 | CL20_MSCV-NUP98::HOXA9-ires-GFP | Express NUP98::HOXA9 in bicistronic retroviral vector |
| 237485 | CL20_MSCV-NUP98::RAP1GDS1-ires-GFP | Express NUP98::RAP1GDS1 in bicistronic retroviral vector |
| 237486 | CCLMPC_HA-NUP98::RAP1GDS1 | Express HA-tagged NUP98::RAP1GDS1 in dual promoter lentiviral vector |
| 237487 | CL20_MSCV-NUP98::JADE2-ires-GFP | Express NUP98::JADE2 in bicistronic retroviral vector |
| 237488 | CCLMPC_HA-NUP98::JADE2 | Express HA-tagged NUP98::JADE2 in dual promoter lentiviral vector |
| 237489 | CL20_MSCV-NUP98::KDM5A-ires-GFP | Express NUP98::KDM5A in bicistronic retroviral vector |
| 237490 | CL20_MSCV-NUP98::SETBP1-ires-GFP | Express NUP98::SETBP1 in bicistronic retroviral vector |
| 237491 | CCLMPC_HA-NUP98::SETBP1 | Express HA-tagged NUP98::SETBP1 in dual promoter lentiviral vector |
| 237492 | CL20_MSCV-NUP98::PRRX1-ires-GFP | Express NUP98::PRRX1 in bicistronic retroviral vector |
| 237493 | CCLMPC_HA-NUP98::PRRX1 | Express HA-tagged NUP98::PRRX1 in dual promoter lentiviral vector |
| 237494 | CL20_MSCV-NUP98::LNP1-ires-GFP | Express NUP98::LNP1 in bicistronic retroviral vector |
| 237495 | CCLMPC_HA-NUP98::LNP1 | Express HA-tagged NUP98::LNP1 in dual promoter lentiviral vector |
| 237496 | CL20_MSCV-ires-GFP | Retroviral empty vector |