Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection.
Hodgson RE, Huang WP, Lang R, Kumar V, An H, Stender EGP, Chalakova ZP, Driver MD, Sanchez Avila A, Ellis BCS, Day E, Rayment JA, Baeg K, Strange A, Moll T, Wright GSA, van Vugt JJFA, Allen SP, Locker N, Pitout I, Fletcher S, Onck PR, Duss O, Cooper-Knock J, Shelkovnikova TA
Nat Cell Biol. 2026 Mar 18. doi: 10.1038/s41556-026-01895-y.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 237543 | TDP-43 2M GFP | Expression of GFP-tag fused to mutant TDP-43 2M |
| 237544 | TDP-43 3M GFP | Expression of GFP-tag fused to mutant TDP-43 3M |
| 237545 | TDP-43 F147/149L GFP | Expression of GFP-tag fused to mutant TDP-43 F147/19L |
| 237546 | TDP-43 ΔNTD GFP | Expression of GFP-tag fused to mutant TDP-43 ΔNTD |
| 237547 | TDP-43 ΔCTD GFP | Expression of GFP-tag fused to mutant TDP-43 ΔCTD |
| 237548 | TDP-43 ΔCR GFP | Expression of GFP-tag fused to mutant TDP-43 ΔCR |
| 237549 | TDP-43 K181E GFP | Expression of GFP-tag fused to mutant TDP-43 K181E |
| 237550 | TDP-43 K181A GFP | Expression of GFP-tag fused to mutant TDP-43 K181A |
| 237551 | Untagged TDP-43 | Expression of untagged wild-type TDP-43 |
| 237552 | SNAP-tag TDP-43 | Expression of SNAP-tag fused to wild-type TDP-43 |