Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production.
Huggler KS, Flickinger KM, Forsberg MH, Mellado Fritz CA, Chang GR, McGuire MF, Capitini CM, Cantor JR
Nat Metab. 2026 Jan 16. doi: 10.1038/s42255-025-01428-1.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 239243 | pLJC2-HK2-3xFLAG | HK2 lentiviral overexpression vector |
| 239244 | pLJC2-HK2 (D209A, D657A)-3xFLAG | HK2 lentiviral overexpression vector |
| 239245 | pLJC2-TOM20-HK2-3xFLAG | TOM20-HK2 lentiviral overexpression vector |
| 239246 | pLJC5-HK2-3xFLAG | HK2 lentiviral overexpression vector |
| 239247 | pLJC5-HK1-3xFLAG | HK1 lentiviral overexpression vector |
| 239248 | pLJC5-3xMyc-eGFP-OMP25 | 3xMyc-eGFP-OMP25 lentiviral overexpression vector |
| 239249 | pLJC5-3xHA-eGFP-OMP25 | 3xHA-eGFP-OMP25 lentiviral overexpression vector |
| 239250 | pLJC6-HK2-3xFLAG | HK2 lentiviral overexpression vector |
| 239251 | pLJC6-HK2 (D209A, D657A)-3xFLAG | HK2 lentiviral overexpression vector |
| 239252 | pLJC6-HK1-3xFLAG | HK1 lentiviral overexpression vector |
| 239253 | pLJC6-HK1 (delta MBD)-3xFLAG | HK1 lentiviral overexpression vector |
| 239254 | pLJC6-HK2 (delta MBD)-3xFLAG | HK2 lentiviral overexpression vector |
| 239255 | pLJC6-MBD1-HK2-3xFLAG | HK2 lentiviral overexpression vector |
| 239256 | pLJC6-TOM20-HK2-3xFLAG | TOM20-HK2 lentiviral overexpression vector |
| 239257 | pLentiCRISPR-v1-sgHK2_14 | lentiviral vector expressing Cas9 and an sgRNA targeting HK2 |