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MFSD6 is an entry receptor for enterovirus D68.

Varanese L, Xu L, Peters CE, Pintilie G, Roberts DS, Raj S, Liu M, Ooi YS, Diep J, Qiao W, Richards CM, Callaway J, Bertozzi CR, Jabs S, de Vries E, van Kuppeveld FJM, Nagamine CM, Chiu W, Carette JE
Nature. 2025 Mar 25. doi: 10.1038/s41586-025-08908-0. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
239947pFUSE-rIgG-Fc2-MFSD8(L9)-ZeoExpression of MFSD8 loop 9 tagged with rabbit IgG Fc2
239948pFUSE-rIgG-Fc2-MFSD6(L3)-ZeoExpression of MFSD6 loop 3 tagged with rabbit IgG Fc2
239949pLentiCRISPRv2-ICAM-5-PuroCRISPR KO of human ICAM-5
239950pLentiCRISPRv2-MFSD6-PuroCRISPR KO of human MFSD6
239951pX458-MFSD6Encodes gRNA for human MFSD6
239953pLenti-CMV-MFSD6-PuroLentiviral vector to generate MFSD6 stable expressing cell line under CMV promoter
239954pLenti-CMV-MFSD8-PuroLentiviral vector to generate MFSD8 stable expressing cell line under CMV promoter
239955pLenti-CMV-MFSD6-mNeon-PuroLentiviral vector to generate mNeon-tagged MFSD6 stable expressing cell line under CMV promoter

Antibodies from Article