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High TNF and NF-kappaB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis.

Chai AWY, Tan YH, Ooi S, Yee PS, Yee SM, Lightfoot H, Barthorpe S, Garnett MJ, Cheong SC
Cancer Res Commun. 2024 Nov 1;4(11):2919-2932. doi: 10.1158/2767-9764.CRC-24-0136. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
208410pKLV2-U6gRNA5(hIKBKG_1k)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human IKBKG gene, co-expression of BFP tag
208411pKLV2-U6gRNA5(hIKBKG_2m)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human IKBKG gene, co-expression of BFP tag
208412pKLV2-U6gRNA5(hMAP3K7_1k)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human MAP3K7 gene, co-expression of BFP tag
208413pKLV2-U6gRNA5(hMAP3K7_2m)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human MAP3K7 gene, co-expression of BFP tag
208414pKLV2-U6gRNA5(hRNF31_1k)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human RNF31 gene, co-expression of BFP tag
208415pKLV2-U6gRNA5(hRNF31_2b)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human RNF31 gene, co-expression of BFP tag
208416pKLV2-U6gRNA5(hBIRC2_1k)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human BIRC2 gene, co-expression of BFP tag
208417pKLV2-U6gRNA5(hBIRC2_2b)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human BIRC2 gene, co-expression of BFP tag
208418pKLV2-U6gRNA5(hBIRC3_1k)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human BIRC3 gene, co-expression of BFP tag
208419pKLV2-U6gRNA5(hBIRC3_2b)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human BIRC3 gene, co-expression of BFP tag
208420pKLV2-U6gRNA5(hXIAP_1k)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human XIAP gene, co-expression of BFP tag
208421pKLV2-U6gRNA5(hXIAP_2b)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human XIAP gene, co-expression of BFP tag
208422pKLV2-U6gRNA5(hCASP8_1k)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human CASP8 gene, co-expression of BFP tag
208423pKLV2-U6gRNA5(hCASP8_2b)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human CASP8 gene, co-expression of BFP tag
208424pKLV2-U6gRNA5(hRIPK3_1k)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human RIPK3 gene, co-expression of BFP tag
208425pKLV2-U6gRNA5(hRIPK3_2b)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human RIPK3 gene, co-expression of BFP tag
208426pKLV2-U6gRNA5(hTNF_2b)-PGKpuro2ABFP-WLentiviral gRNA plasmid targeting human TNF gene, co-expression of BFP tag

Antibodies from Article