A streamlined base editor engineering strategy to reduce bystander editing.
Valdez I, O'Connor I, Patel D, Gierer K, Harrington J, Ellis E, Caponetti SA, Sebra RP, Valley HC, Coote K, Mense M, Marro SG, Jiang T
Nat Commun. 2025 Aug 30;16(1):8115. doi: 10.1038/s41467-025-63609-6.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 240615 | ABE-NW1 | Adenine base editor with narrowed editing window |
| 240616 | ABE-NW2 | Adenine base editor with narrowed editing window |
| 240617 | ABE-NW3 | Adenine base editor with narrowed editing window |
| 240618 | ABE-NW4 | Adenine base editor with narrowed editing window |
| 240619 | ABE-NW5 | Adenine base editor with narrowed editing window |
| 240620 | ABE-NW6 | Adenine base editor with narrowed editing window |
| 240621 | ABE-NW-NL | Adenine base editor with narrowed editing window |
| 240622 | NG-ABE-NW | Adenine base editor with narrowed editing window, recognizing NG PAM |
| 240623 | Td-CBE-NW | Cytidine base editor with narrowed editing window |
| 240624 | ACBE-NW | A-to-C base editor with narrowed editing window |
| 240625 | NG-ABE9 | Adenine base editor with narrowed editing window, recognizing NG PAM |