Computationally designed proteins mimic antibody immune evasion in viral evolution.
Youssef N, Gurev S, Ghantous F, Brock KP, Jaimes JA, Thadani NN, Dauphin A, Sherman AC, Yurkovetskiy L, Soto D, Estanboulieh R, Kotzen B, Notin P, Kollasch AW, Cohen AA, Dross SE, Erasmus J, Fuller DH, Bjorkman PJ, Lemieux JE, Luban J, Seaman MS, Marks DS
Immunity. 2025 May 6:S1074-7613(25)00178-5. doi: 10.1016/j.immuni.2025.04.015.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 241032 | pDMJ2-SARS-CoV-2-Spike (Alpha) | Expresses SARS-CoV-2 spike (Alpha) protein for creating pseudotyped virus |
| 241033 | pDMJ2-SARS-CoV-2-Spike (B.1) | Expresses SARS-CoV-2 spike (B.1) protein for creating pseudotyped virus |
| 241034 | pDMJ2-SARS-CoV-2-Spike (B.1-10a) | Expresses SARS-CoV-2 spike (B.1-10a) protein for creating pseudotyped virus |
| 241035 | pDMJ2-SARS-CoV-2-Spike (B.1-10b) | Expresses SARS-CoV-2 spike (B.1-10b) protein for creating pseudotyped virus |
| 241037 | pDMJ2-SARS-CoV-2-Spike (B.1-10d) | Expresses SARS-CoV-2 spike (B.1-10d) protein for creating pseudotyped virus |
| 241038 | pDMJ2-SARS-CoV-2-Spike (B.1-2a) | Expresses SARS-CoV-2 spike (B.1-2a) protein for creating pseudotyped virus |
| 241039 | pDMJ2-SARS-CoV-2-Spike (B.1-2b) | Expresses SARS-CoV-2 spike (B.1-2b) protein for creating pseudotyped virus |
| 241040 | pDMJ2-SARS-CoV-2-Spike (B.1-2c) | Expresses SARS-CoV-2 spike (B.1-2c) protein for creating pseudotyped virus |
| 241041 | pDMJ2-SARS-CoV-2-Spike (B.1-2d) | Expresses SARS-CoV-2 spike (B.1-2d) protein for creating pseudotyped virus |
| 241042 | pDMJ2-SARS-CoV-2-Spike (B.1-4a) | Expresses SARS-CoV-2 spike (B.1-4a) protein for creating pseudotyped virus |
| 241043 | pDMJ2-SARS-CoV-2-Spike (B.1-4d) | Expresses SARS-CoV-2 spike (B.1-4d) protein for creating pseudotyped virus |
| 241044 | pDMJ2-SARS-CoV-2-Spike (B.1-4b) | Expresses SARS-CoV-2 spike (B.1-4b) protein for creating pseudotyped virus |
| 241045 | pDMJ2-SARS-CoV-2-Spike (B.1-4c) | Expresses SARS-CoV-2 spike (B.1-4c) protein for creating pseudotyped virus |
| 241046 | pDMJ2-SARS-CoV-2-Spike (B.1-5a) | Expresses SARS-CoV-2 spike (B.1-5a) protein for creating pseudotyped virus |
| 241047 | pDMJ2-SARS-CoV-2-Spike (B.1-8a) | Expresses SARS-CoV-2 spike (B.1-8a) protein for creating pseudotyped virus |
| 241048 | pDMJ2-SARS-CoV-2-Spike (B.1-8b) | Expresses SARS-CoV-2 spike (B.1-8b) protein for creating pseudotyped virus |
| 241049 | pDMJ2-SARS-CoV-2-Spike (B.1-8c) | Expresses SARS-CoV-2 spike (B.1-8c) protein for creating pseudotyped virus |
| 241050 | pDMJ2-SARS-CoV-2-Spike (B.1-8d) | Expresses SARS-CoV-2 spike (B.1-8d) protein for creating pseudotyped virus |
| 241051 | pDMJ2-SARS-CoV-2-Spike (B.1-9a) | Expresses SARS-CoV-2 spike (B.1-9a) protein for creating pseudotyped virus |
| 241052 | pDMJ2-SARS-CoV-2-Spike (B.1-9b) | Expresses SARS-CoV-2 spike (B.1-9b) protein for creating pseudotyped virus |
| 241053 | pDMJ2-SARS-CoV-2-Spike (B.1-9c) | Expresses SARS-CoV-2 spike (B.1-9c) protein for creating pseudotyped virus |
| 241056 | pDMJ2-SARS-CoV-2-Spike (BA.2) | Expresses SARS-CoV-2 spike (BA.2) protein for creating pseudotyped virus |
| 241057 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1) | Expresses SARS-CoV-2 spike (BA.2.12.1) protein for creating pseudotyped virus |
| 241058 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-2a) | Expresses SARS-CoV-2 spike (BA.2.12.1-2a) protein for creating pseudotyped virus |
| 241059 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-2h) | Expresses SARS-CoV-2 spike (BA.2.12.1-2h) protein for creating pseudotyped virus |
| 241060 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-2c) | Expresses SARS-CoV-2 spike (BA.2.12.1-2c) protein for creating pseudotyped virus |
| 241061 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-2d) | Expresses SARS-CoV-2 spike (BA.2.12.1-2d) protein for creating pseudotyped virus |
| 241062 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-2e) | Expresses SARS-CoV-2 spike (BA.2.12.1-2e) protein for creating pseudotyped virus |
| 241063 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-2f) | Expresses SARS-CoV-2 spike (BA.2.12.1-2f) protein for creating pseudotyped virus |
| 241064 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-2g) | Expresses SARS-CoV-2 spike (BA.2.12.1-2g) protein for creating pseudotyped virus |
| 241065 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-4a) | Expresses SARS-CoV-2 spike (BA.2.12.1-4a) protein for creating pseudotyped virus |
| 241066 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-4b) | Expresses SARS-CoV-2 spike (BA.2.12.1-4b) protein for creating pseudotyped virus |
| 241067 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-5a) | Expresses SARS-CoV-2 spike (BA.2.12.1-5a) protein for creating pseudotyped virus |
| 241068 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-7a) | Expresses SARS-CoV-2 spike (BA.2.12.1-7a) protein for creating pseudotyped virus |
| 241069 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-8a) | Expresses SARS-CoV-2 spike (BA.2.12.1-8a) protein for creating pseudotyped virus |
| 241070 | pDMJ2-SARS-CoV-2-Spike (BA.2.12.1-9a) | Expresses SARS-CoV-2 spike (BA.2.12.1-9a) protein for creating pseudotyped virus |
| 241071 | pDMJ2-SARS-CoV-2-Spike (BA.2.75) | Expresses SARS-CoV-2 spike (BA.2.75) protein for creating pseudotyped virus |
| 241072 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-2a) | Expresses SARS-CoV-2 spike (BA.2.75-2a) protein for creating pseudotyped virus |
| 241073 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-2b) | Expresses SARS-CoV-2 spike (BA.2.75-2b) protein for creating pseudotyped virus |
| 241074 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-3a) | Expresses SARS-CoV-2 spike (BA.2.75-3a) protein for creating pseudotyped virus |
| 241075 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-3b) | Expresses SARS-CoV-2 spike (BA.2.75-3b) protein for creating pseudotyped virus |
| 241076 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-4a) | Expresses SARS-CoV-2 spike (BA.2.75-4a) protein for creating pseudotyped virus |
| 241077 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-4b) | Expresses SARS-CoV-2 spike (BA.2.75-4b) protein for creating pseudotyped virus |
| 241078 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-4c) | Expresses SARS-CoV-2 spike (BA.2.75-4c) protein for creating pseudotyped virus |
| 241079 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-4d) | Expresses SARS-CoV-2 spike (BA.2.75-4d) protein for creating pseudotyped virus |
| 241080 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-4e) | Expresses SARS-CoV-2 spike (BA.2.75-4e) protein for creating pseudotyped virus |
| 241081 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-5a) | Expresses SARS-CoV-2 spike (BA.2.75-5a) protein for creating pseudotyped virus |
| 241082 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-5b) | Expresses SARS-CoV-2 spike (BA.2.75-5b) protein for creating pseudotyped virus |
| 241083 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-5c) | Expresses SARS-CoV-2 spike (BA.2.75-5c) protein for creating pseudotyped virus |
| 241084 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-5d) | Expresses SARS-CoV-2 spike (BA.2.75-5d) protein for creating pseudotyped virus |
| 241085 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-6a) | Expresses SARS-CoV-2 spike (BA.2.75-6a) protein for creating pseudotyped virus |
| 241086 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-6b) | Expresses SARS-CoV-2 spike (BA.2.75-6b) protein for creating pseudotyped virus |
| 241087 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-6c) | Expresses SARS-CoV-2 spike (BA.2.75-6c) protein for creating pseudotyped virus |
| 241088 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-8a) | Expresses SARS-CoV-2 spike (BA.2.75-8a) protein for creating pseudotyped virus |
| 241089 | pDMJ2-SARS-CoV-2-Spike (BA.2.75-9a) | Expresses SARS-CoV-2 spike (BA.2.75-9a) protein for creating pseudotyped virus |
| 241090 | pDMJ2-SARS-CoV-2-Spike (BA.2.86) | Expresses SARS-CoV-2 spike (BA.2.86) protein for creating pseudotyped virus |
| 241091 | pDMJ2-SARS-CoV-2-Spike (BA.5) | Expresses SARS-CoV-2 spike (BA.5) protein for creating pseudotyped virus |
| 241092 | pDMJ2-SARS-CoV-2-Spike (BA.5-1a) | Expresses SARS-CoV-2 spike (BA.5-1a) protein for creating pseudotyped virus |
| 241093 | pDMJ2-SARS-CoV-2-Spike (BA.5-1b) | Expresses SARS-CoV-2 spike (BA.5-1b) protein for creating pseudotyped virus |
| 241094 | pDMJ2-SARS-CoV-2-Spike (BA.5-1c) | Expresses SARS-CoV-2 spike (BA.5-1c) protein for creating pseudotyped virus |
| 241095 | pDMJ2-SARS-CoV-2-Spike (BA.5-1d) | Expresses SARS-CoV-2 spike (BA.5-1d) protein for creating pseudotyped virus |
| 241096 | pDMJ2-SARS-CoV-2-Spike (BA.5-1e) | Expresses SARS-CoV-2 spike (BA.5-1e) protein for creating pseudotyped virus |
| 241097 | pDMJ2-SARS-CoV-2-Spike (BA.5-1f) | Expresses SARS-CoV-2 spike (BA.5-1f) protein for creating pseudotyped virus |
| 241098 | pDMJ2-SARS-CoV-2-Spike (BA.5-1g) | Expresses SARS-CoV-2 spike (BA.5-1g) protein for creating pseudotyped virus |
| 241099 | pDMJ2-SARS-CoV-2-Spike (BA.5-2a) | Expresses SARS-CoV-2 spike (BA.5-2a) protein for creating pseudotyped virus |
| 241100 | pDMJ2-SARS-CoV-2-Spike (BA.5-2c) | Expresses SARS-CoV-2 spike (BA.5-2c) protein for creating pseudotyped virus |
| 241101 | pDMJ2-SARS-CoV-2-Spike (BA.5-2d) | Expresses SARS-CoV-2 spike (BA.5-2d) protein for creating pseudotyped virus |
| 241103 | pDMJ2-SARS-CoV-2-Spike (BA.5-2f) | Expresses SARS-CoV-2 spike (BA.5-2f) protein for creating pseudotyped virus |
| 241104 | pDMJ2-SARS-CoV-2-Spike (BA.5-3a) | Expresses SARS-CoV-2 spike (BA.5-3a) protein for creating pseudotyped virus |
| 241105 | pDMJ2-SARS-CoV-2-Spike (BA.5-3b) | Expresses SARS-CoV-2 spike (BA.5-3b) protein for creating pseudotyped virus |
| 241106 | pDMJ2-SARS-CoV-2-Spike (BA.5-4a) | Expresses SARS-CoV-2 spike (BA.5-4a) protein for creating pseudotyped virus |
| 241107 | pDMJ2-SARS-CoV-2-Spike (BA.5-5a) | Expresses SARS-CoV-2 spike (BA.5-5a) protein for creating pseudotyped virus |
| 241108 | pDMJ2-SARS-CoV-2-Spike (BA.5-5b) | Expresses SARS-CoV-2 spike (BA.5-5b) protein for creating pseudotyped virus |
| 241109 | pDMJ2-SARS-CoV-2-Spike (Beta) | Expresses SARS-CoV-2 spike (Beta) protein for creating pseudotyped virus |
| 241110 | pDMJ2-SARS-CoV-2-Spike (BQ.1) | Expresses SARS-CoV-2 spike (BQ.1) protein for creating pseudotyped virus |
| 241111 | pDMJ2-SARS-CoV-2-Spike (BQ.1.1) | Expresses SARS-CoV-2 spike (BQ.1.1) protein for creating pseudotyped virus |
| 241113 | pDMJ2-SARS-CoV-2-Spike (Delta) | Expresses SARS-CoV-2 spike (Delta) protein for creating pseudotyped virus |
| 241114 | pDMJ2-SARS-CoV-2-Spike (EG.5) | Expresses SARS-CoV-2 spike (EG.5) protein for creating pseudotyped virus |
| 241115 | pDMJ2-SARS-CoV-2-Spike (Gamma) | Expresses SARS-CoV-2 spike (Gamma) protein for creating pseudotyped virus |
| 241116 | pDMJ2-SARS-CoV-2-Spike (HV.1) | Expresses SARS-CoV-2 spike (HV.1) protein for creating pseudotyped virus |
| 241117 | pDMJ2-SARS-CoV-2-Spike (JN.1) | Expresses SARS-CoV-2 spike (JN.1) protein for creating pseudotyped virus |
| 241118 | pDMJ2-SARS-CoV-2-Spike (XBB) | Expresses SARS-CoV-2 spike (XBB) protein for creating pseudotyped virus |
| 241119 | pDMJ2-SARS-CoV-2-Spike (XBB-10a) | Expresses SARS-CoV-2 spike (XBB-10a) protein for creating pseudotyped virus |
| 241120 | pDMJ2-SARS-CoV-2-Spike (XBB-10b) | Expresses SARS-CoV-2 spike (XBB-10b) protein for creating pseudotyped virus |
| 241121 | pDMJ2-SARS-CoV-2-Spike (XBB-1a) | Expresses SARS-CoV-2 spike (XBB-1a) protein for creating pseudotyped virus |
| 241122 | pDMJ2-SARS-CoV-2-Spike (XBB-2a) | Expresses SARS-CoV-2 spike (XBB-2a) protein for creating pseudotyped virus |
| 241123 | pDMJ2-SARS-CoV-2-Spike (XBB-3a) | Expresses SARS-CoV-2 spike (XBB-3a) protein for creating pseudotyped virus |
| 241124 | pDMJ2-SARS-CoV-2-Spike (XBB-4a) | Expresses SARS-CoV-2 spike (XBB-4a) protein for creating pseudotyped virus |
| 241125 | pDMJ2-SARS-CoV-2-Spike (XBB-5a) | Expresses SARS-CoV-2 spike (XBB-5a) protein for creating pseudotyped virus |
| 241126 | pDMJ2-SARS-CoV-2-Spike (XBB-5b) | Expresses SARS-CoV-2 spike (XBB-5b) protein for creating pseudotyped virus |
| 241127 | pDMJ2-SARS-CoV-2-Spike (XBB-5c) | Expresses SARS-CoV-2 spike (XBB-5c) protein for creating pseudotyped virus |
| 241128 | pDMJ2-SARS-CoV-2-Spike (XBB-6a) | Expresses SARS-CoV-2 spike (XBB-6a) protein for creating pseudotyped virus |
| 241129 | pDMJ2-SARS-CoV-2-Spike (XBB-8a) | Expresses SARS-CoV-2 spike (XBB-8a) protein for creating pseudotyped virus |
| 241130 | pDMJ2-SARS-CoV-2-Spike (XBB-8b) | Expresses SARS-CoV-2 spike (XBB-8b) protein for creating pseudotyped virus |
| 241131 | pDMJ2-SARS-CoV-2-Spike (XBB-9a) | Expresses SARS-CoV-2 spike (XBB-9a) protein for creating pseudotyped virus |
| 241132 | pDMJ2-SARS-CoV-2-Spike (XBB-9b) | Expresses SARS-CoV-2 spike (XBB-9b) protein for creating pseudotyped virus |
| 241133 | pDMJ2-SARS-CoV-2-Spike (XBB.1) | Expresses SARS-CoV-2 spike (XBB.1) protein for creating pseudotyped virus |