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Repetitive proteins that undergo large conformational changes evade structural prediction algorithms.

Chang MP, Jin T, Gudinas AP, Fernandez D, Alexander-Katz A, Matsui T, Mai DJ
J Chem Phys. 2025 Dec 14;163(22):224906. doi: 10.1063/5.0304777. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
241346pQE-9-RTXMCR-TYL-X2A-CRepeats-In-Toxin (RTX) protein consensus sequence GGAGADTYL repeated nine times with C-terminal Capping Domain
241347pQE-9-RTXMCR-TYL-X2D-CRepeats-In-Toxin (RTX) protein consensus sequence GGAGDDTYL repeated nine times with C-terminal Capping Domain
241348pQE-9-RTXMCR-TYL-X2E-CRepeats-In-Toxin (RTX) protein consensus sequence GGAGEDTYL repeated nine times with C-terminal Capping Domain
241349pQE-9-RTXMCR-TYL-X2H-CRepeats-In-Toxin (RTX) protein consensus sequence GGAGHDTYL repeated nine times with C-terminal Capping Domain
241350pQE-9-RTXMCR-TYL-X2N-CRepeats-In-Toxin (RTX) protein consensus sequence GGAGNDTYL repeated nine times with C-terminal Capping Domain
241351pQE-9-RTXMCR-TYL-X2S-CRepeats-In-Toxin (RTX) protein consensus sequence GGAGSDTYL repeated nine times with C-terminal Capping Domain

Antibodies from Article