Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.
Liang X, Gupta D, Xie J, Van Wonterghem E, Van Hoecke L, Hean J, Niu Z, Ghaeidamini M, Wiklander OPB, Zheng W, Wiklander RJ, He R, Mamand DR, Bost J, Zhou G, Zhou H, Roudi S, Estupinan HY, Radler J, Zickler AM, Gorgens A, Hou VWQ, Slovak R, Hagey DW, de Jong OG, Uy AG, Zong Y, Mager I, Perez CM, Roberts TC, Carter D, Vader P, Esbjorner EK, de Fougerolles A, Wood MJA, Vandenbroucke RE, Nordin JZ, El Andaloussi S
Nat Commun. 2025 Apr 29;16(1):4028. doi: 10.1038/s41467-025-59377-y.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 247722 | pLEX-CD63-Intein-Cre | Expresses EV-Sorting domain CD63 and Cre recombinase, separated by self-cleaving intein |
| 247729 | pLEX-VSV-G-Foldon-Intein-Cre | Expresses VSV-G, Foldon and Cre recombinase, separated by self-cleaving intein |
| 247730 | pLEX-CD63-Intein-Cas9 | Expresses EV-Sorting domain CD63 and Cas9, separated by self-cleaving intein |
| 247731 | pLEX-VSV-G-Foldon-Intein-Cas9 | Expresses VSV-G, Foldon and Cas9, separated by self-cleaving intein |