Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.
van der Plas – van Duijn A, Winkelman L, Lensen C, van Duivendijk M, Derksen I, van Veenendaal J, Schaap G, Sluijter M, van Groningen T, van Doorn R, van Hall T, Slieker R, Sharp T, Beltman J, Bresser K, Scheeren F
Commun Biol 8, 1561 (2025).
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 242866 | cleaveBADTrp | Expression of cleavable Trp1 (extracellular domain) |
| 242867 | Trp1-WT-display | Expression of ECD of WT- Trp1 fused to display TMD. |
| 242868 | Trp1-Ala-display | Expression of ECD of Trp-1-ala fused to display TMD. |