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ABE9 fused to SpRY Cas9 nickase enables precise generation of bystander free mouse models.

Ong JK, Bhunia S, Hilbert B, Kirschner V, Duglosz S, Zimmermann F, Freichel M, Cornean A
Sci Rep. 2026 Feb 20;16(1):7463. doi: 10.1038/s41598-026-40642-z. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
242976ABE9-SpRYA-to-G base editor fused to PAM-flexible SpRY-Cas9 nickase.
242977pEF1a_ABE9-SpRYA-to-G base editor fused to PAM-flexible SpRY-Cas9 nickase.

Antibodies from Article