The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation.
Anuncibay Soto B, Ma Y, Nollet M, Wong S, Miracca G, Rastinejad D, Yustos R, Vyssotski AL, Franks NP, Wisden W
Proc Natl Acad Sci U S A. 2025 Oct 14;122(41):e2422878122. doi: 10.1073/pnas.2422878122. Epub 2025 Oct 7.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 245063 | pAAV-hsynapsin-DIO-adra2a-shRNA-mCherry | AAV-transgene knocking down adra2a receptor (adrenergic 2a receptor) transcripts cell type-selectively. Using the pPRIME. system, this generates mir30-derived shRNAs and a marker from the same RNA. |
| 245064 | pAAV-hsynapsin-DIO-scramble shRNA - mCherry | AAV transgene designes to express scramble (control) shRNA sequence cell-type selectively. Scramble hairpin expressed from the mir30 cassette together with mCherry. |