The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain.
van Vlimmeren AE, Voleti R, Chartier CA, Jiang Z, Karandur D, Humphries PA, Lo WL, Shah NH
Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2407159121. doi: 10.1073/pnas.2407159121. Epub 2024 Jul 16.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 245190 | pET-SUMO-SHP2-C-SH2(E139D)-Avi | Production of N-terminally His-SUMO-tagged and C-terminally Avi-tagged SH2 domain |
| 245191 | pET-28b His6-TEV-SHP2-FL(WT) | Production of His-tagged full-length SHP2 |