The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2.
van Vlimmeren AE, Jiang Z, Karandur D, Applebaum Licht AT, Shah NH
bioRxiv [Preprint]. 2025 Jul 4:2025.07.02.662799. doi: 10.1101/2025.07.02.662799.
(Link opens in a new window)
PubMed
(Link opens in a new window)
Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 245192 | pET-28b His6-TEV-SHP2-FL(R4A) | Production of His-tagged full-length SHP2 |
| 245193 | pET-28b His6-TEV-SHP2-FL(R5A) | Production of His-tagged full-length SHP2 |
| 245194 | pET-28b His6-TEV-SHP2-FL(R4A,R5A) | Production of His-tagged full-length SHP2 |
| 245207 | pET-28b His6-TEV-SHP2-FL(E139A) | Production of His-tagged full-length SHP2 |