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Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants.

van Vlimmeren AE, Giglio RM, Jiang Z, Lee M, McFaline-Figueroa JL, Shah NH
bioRxiv [Preprint]. 2025 Jul 2:2025.06.30.662374. doi: 10.1101/2025.06.30.662374. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
245214pET-28b His6-TEV-SHP2-FL(Q510E)Production of His-tagged full-length SHP2
245215pET-28b His6-TEV-SHP2-FL(Q510K)Production of His-tagged full-length SHP2
245216pET-NIC-His6-TEV-SHP2-PTP(WT)Production of His-tagged SHP2 PTP domain
245217pET-NIC-His6-TEV-SHP2-PTP(T507K)Production of His-tagged SHP2 PTP domain
245218pET-NIC-His6-TEV-SHP2-PTP(Q510E)Production of His-tagged SHP2 PTP domain
245219pET-NIC-His6-TEV-SHP2-PTP(Q510K)Production of His-tagged SHP2 PTP domain
245226pEF myc-SHP2(T52S)Mammalian expression of myc-tagged full-length SHP2
245229pEF myc-SHP2(E139D)Mammalian expression of myc-tagged full-length SHP2
245230pEF myc-SHP2(Y279C)Mammalian expression of myc-tagged full-length SHP2
245232pEF myc-SHP2(Q506P)Mammalian expression of myc-tagged full-length SHP2
245233pEF myc-SHP2(Q510E)Mammalian expression of myc-tagged full-length SHP2
245234pEF myc-SHP2(Q510H)Mammalian expression of myc-tagged full-length SHP2
245236pEF myc-SHP2(Q510L)Mammalian expression of myc-tagged full-length SHP2
245237pEF myc-SHP2(Q510R)Mammalian expression of myc-tagged full-length SHP2

Antibodies from Article