Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants.
van Vlimmeren AE, Giglio RM, Jiang Z, Lee M, McFaline-Figueroa JL, Shah NH
bioRxiv [Preprint]. 2025 Jul 2:2025.06.30.662374. doi: 10.1101/2025.06.30.662374.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 245214 | pET-28b His6-TEV-SHP2-FL(Q510E) | Production of His-tagged full-length SHP2 |
| 245215 | pET-28b His6-TEV-SHP2-FL(Q510K) | Production of His-tagged full-length SHP2 |
| 245216 | pET-NIC-His6-TEV-SHP2-PTP(WT) | Production of His-tagged SHP2 PTP domain |
| 245217 | pET-NIC-His6-TEV-SHP2-PTP(T507K) | Production of His-tagged SHP2 PTP domain |
| 245218 | pET-NIC-His6-TEV-SHP2-PTP(Q510E) | Production of His-tagged SHP2 PTP domain |
| 245219 | pET-NIC-His6-TEV-SHP2-PTP(Q510K) | Production of His-tagged SHP2 PTP domain |
| 245226 | pEF myc-SHP2(T52S) | Mammalian expression of myc-tagged full-length SHP2 |
| 245229 | pEF myc-SHP2(E139D) | Mammalian expression of myc-tagged full-length SHP2 |
| 245230 | pEF myc-SHP2(Y279C) | Mammalian expression of myc-tagged full-length SHP2 |
| 245232 | pEF myc-SHP2(Q506P) | Mammalian expression of myc-tagged full-length SHP2 |
| 245233 | pEF myc-SHP2(Q510E) | Mammalian expression of myc-tagged full-length SHP2 |
| 245234 | pEF myc-SHP2(Q510H) | Mammalian expression of myc-tagged full-length SHP2 |
| 245236 | pEF myc-SHP2(Q510L) | Mammalian expression of myc-tagged full-length SHP2 |
| 245237 | pEF myc-SHP2(Q510R) | Mammalian expression of myc-tagged full-length SHP2 |