Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants.
van Vlimmeren AE, Giglio RM, Jiang Z, Lee M, McFaline-Figueroa JL, Shah NH
bioRxiv [Preprint]. 2025 Jul 2:2025.06.30.662374. doi: 10.1101/2025.06.30.662374.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 245214 | pET-28b His6-TEV-SHP2-FL(Q510E) | Production of His-tagged full-length SHP2 |
| 245215 | pET-28b His6-TEV-SHP2-FL(Q510K) | Production of His-tagged full-length SHP2 |
| 245216 | pET-NIC-His6-TEV-SHP2-PTP(WT) | Production of His-tagged SHP2 PTP domain |
| 245218 | pET-NIC-His6-TEV-SHP2-PTP(Q510E) | Production of His-tagged SHP2 PTP domain |
| 245219 | pET-NIC-His6-TEV-SHP2-PTP(Q510K) | Production of His-tagged SHP2 PTP domain |