Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants.
van Vlimmeren AE, Tang LC, Jiang Z, Iyer A, Voleti R, Krismer K, Gaublomme JT, Jovanovic M, Shah NH
bioRxiv [Preprint]. 2025 Mar 21:2025.02.26.640373. doi: 10.1101/2025.02.26.640373.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 245221 | pEF myc-SHP2(R4A,R5A) | Mammalian expression of myc-tagged full-length SHP2 |
| 245228 | pEF myc-SHP2(R138Q) | Mammalian expression of myc-tagged full-length SHP2 |
| 245231 | pEF myc-SHP2(T468M) | Mammalian expression of myc-tagged full-length SHP2 |
| 245235 | pEF myc-SHP2(Q510K) | Mammalian expression of myc-tagged full-length SHP2 |
| 245241 | pEF myc-TurboID | Proximity-labeling proteomics negative control |
| 245242 | pEF myc-SHP2(WT)-TurboID | Proximity-labeling proteomics with SHP2 |
| 245243 | pEF myc-SHP2(T42A)-TurboID | Proximity-labeling proteomics with SHP2 |
| 245244 | pEF myc-SHP2(T52S)-TurboID | Proximity-labeling proteomics with SHP2 |
| 245245 | pEF myc-SHP2(E76K)-TurboID | Proximity-labeling proteomics with SHP2 |
| 245247 | pEF myc-SHP2(E139D)-TurboID | Proximity-labeling proteomics with SHP2 |
| 245248 | pEF myc-SHP2(Y279C)-TurboID | Proximity-labeling proteomics with SHP2 |
| 245249 | pEF myc-SHP2(T507K)-TurboID | Proximity-labeling proteomics with SHP2 |
| 245250 | pEF myc-SHP2(Q510E)-TurboID | Proximity-labeling proteomics with SHP2 |
| 245251 | pEF myc-SHP2(Q510K)-TurboID | Proximity-labeling proteomics with SHP2 |