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Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.

Pechincha C, Groessl S, Kalis R, de Almeida M, Zanotti A, Wittmann M, Schneider M, de Campos RP, Rieser S, Brandstetter M, Schleiffer A, Muller-Decker K, Helm D, Jabs S, Haselbach D, Lemberg MK, Zuber J, Palm W
Science. 2022 Oct 7;378(6615):eabn5637. doi: 10.1126/science.abn5637. Epub 2022 Oct 7. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
246080pBabe_LYSET_isoform1Stable expression of LYSET isoform 1 (long isoform)
246081pBabe_LYSET_isoform2Stable expression of LYSET isoform 2 (short isoform)
246082pRRL_LYSETStable expression of LYSET (isoform 2)
246083pRRL_LYSET_R7WStable expression of LYSET R7W (isoform 2; R45W in isoform 1)
246084pRRL_LYSET_Y34XStable expression of LYSET Y34X (isoform 2; Y72X in isoform 1)

Antibodies from Article