Infigratinib is a weak inhibitor of the FGFR3-N540K mutant associated with hypochondroplasia.
Ursachi VC, Feketova Z, Czyrek AA, Sestakova K, Svozilova K, Rico-Llanos G, Krejci P
J Bone Miner Res. 2026 Jan 26:zjag017. doi: 10.1093/jbmr/zjag017.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 246390 | pTR01F/hFGFR3c-N540K-V5 | for PiggyBac mediated integration and stable expression of hFGFR3c-N540K protein, mutant variant causes Hypochondroplasia and Thanatophoric dysplasia |