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Self-splicing RNA circularization facilitated by intact group I and II introns.

Shen Y, Li B, Dong L, Tang W, Ren J, Chen F, Zheng W, Yu Y, Gao L, Wei W
Nat Commun. 2025 Aug 10;16(1):7376. doi: 10.1038/s41467-025-62607-y. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
246753CIRC-Scarless-Ana-CVB3 IRES split 403-mCherryGenerate scarless circRNA with CVB3 IRES
246754CIRC-V1-Ana-CVB3 IRES-EGFP-BbsIRNA circularization with CIRC using Ana intron, harbouring an CVB3 IRES-EGFP reporter.Plasmid was linearized with BbsI.
246755CIRC-V1-Ana-CVB3 IRES-EGFP-BsaIRNA circularization with CIRC using Ana intron, harbouring an CVB3 IRES-EGFP reporter.Plasmid was linearized with BsaI.
246756CIRC-V1-Tet-CVB3 IRES-EGFP-BbsIRNA circularization with CIRC using Tet intron, harbouring an CVB3 IRES-EGFP reporter.Plasmid was linearized with BbsI.
246757CIRC-V1-Azo-CVB3 IRES-EGFP-BbsIRNA circularization with CIRC using Azo intron, harbouring an CVB3 IRES-EGFP reporter.Plasmid was linearized with BbsI.

Antibodies from Article