Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains
Otani Y, Goodall E, Srinivasan V, Ball NJ, Barnett SFH, Zech T, Saarikangas J, Goult BT
bioRxiv 2025.08.27.672337; doi: https://doi.org/10.1101/2025.08.27.672337
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 245899 | GFP-CDKL5(isoform1) | Mammalian expression of CDKL5 isoform1 (1-960) with N-terminal GFP |
| 245900 | GFP-CDKL5(isoform1)_L960D | Mammalian expression of CDKL5 isoform1 (1-960) L960D with N-terminal GFP |
| 245903 | CDKL5(isoform1)-GFP | Mammalian expression of CDKL5 isoform1 (1-960) with C-terminal GFP |
| 245904 | hPSD-95_PDZ2 | Bacterial expression of PSD-95 PDZ2 domain (155-249) |
| 245905 | hPSD-95_PDZ3 | Bacterial expression of PSD-95 PDZ3 domain (302-402) |
| 245906 | mSHANK1_PDZ | Bacterial expression of SHANK1 PDZ domain (654-762) |
| 245907 | mSHANK2_PDZ | Bacterial expression of SHANK2 PDZ domain (247-340) |
| 245908 | mSHANK3_PDZ | Bacterial expression of SHANK3 PDZ domain (570-664) |