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Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.

Pulschen AA, Booth J, Satanowski A, Soudy C, Caro-Astorga J, Ather O, Patel N, Alidoust A, Aoudjane S, Nematollahi L, DeBenedictis E
Nat Commun. 2026 Mar 24. doi: 10.1038/s41467-026-70981-4. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
247093pJB21x05Expression of RgnTDC
247094pJB15x02In vivo expression of wild-type Enterocin RJ-11
247095pJB15x06v2In vivo expression of Enterocin RJ-11 (W30 TAG)
247096pJB18x02v1Production of SUMO-Enterocin RJ-11 W307-Cl
247097pAP65Contains WT RebH
247098pAP113Contains RebHEvo4
247099pAP54Contains Fre-L3-RebH (WT)
247100pAP114Contains Fre-L3-RebHEvo4
247101pAP79Contains ChPheRS4*S333C
247102pAP80Contains ChPheRS4*S333C, M490I
247103pAP70Contains pIII*1TAG + Fre

Antibodies from Article