Programming tissue-sensing T cells that deliver therapies to the brain.
Simic MS, Watchmaker PB, Gupta S, Wang Y, Sagan SA, Duecker J, Shepherd C, Diebold D, Pineo-Cavanaugh P, Haegelin J, Zhu R, Ng B, Yu W, Tonai Y, Cardarelli L, Reddy NR, Sidhu SS, Troyanskaya O, Hauser SL, Wilson MR, Zamvil SS, Okada H, Lim WA
Science. 2024 Dec 6;386(6726):eadl4237. doi: 10.1126/science.adl4237. Epub 2024 Dec 6.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 247467 | pHR-SFFV- MOG-VHVL-M26-synNotch-Gal4VP64 | Expresses a synNotch binding to myelin oligodendrocyte glycoprotein |
| 247501 | pHR-SFFV- MOG-VHVL-M38-synNotch-Gal4VP64 | Expresses a synNotch binding to myelin oligodendrocyte glycoprotein |
| 247502 | pHR-SFFV- MOG-VHVL-M38-synNotch-Gal4VP64 | Expresses a synNotch binding to myelin oligodendrocyte glycoprotein |
| 247503 | pHR-PGK- CDH10#1-synNotch-Gal4VP64 | Expresses a synNotch binding to CDH10 (cadherin 10) |
| 247504 | pHR-PGK- CDH10#3-synNotch-Gal4VP64 | Expresses a synNotch binding to CDH10 (cadherin 10) |
| 247508 | pHR_PGK 3XFlag_4D5-5_CAR-mCherry | Expresses a CAR against HER2 and mCherry |
| 247511 | pHR_PGK_ anti-NRCAM 12955 (VL + VH) synNotch | Expresses a synNotch binding to NrCAM (neural cell adhesion molecule) |
| 247512 | pHR_PGK_ anti-NRCAM 12955 (VH+VL) synNotch | Expresses a synNotch binding to NrCAM (neural cell adhesion molecule) |
| 247514 | pHR_PGK_ anti-CSPG5 12959 (VH+VL) synNotch | Expresses a synNotch receptor binding to CSPG5 |
| 247515 | pHR_PGK_ anti-CSPG5 12963 (VL+VH) synNotch | Expresses a synNotch receptor binding to CSPG5 |
| 247516 | pHR_PGK_ anti-CSPG5 12963 (VH+VL) synNotch | Expresses a synNotch receptor binding to CSPG5 |
| 247517 | pHR_PGK_ anti-PTPRZ CA domain 13058 (VL+VH) synNotch | Expresses a synNotch receptor binding to PTPRZ |
| 247518 | pHR_PGK_ anti-PTPRZ CA domain 13058 (VH+VL) synNotch | Expresses a synNotch receptor binding to PTPRZ |
| 247519 | pHR_PGK_ anti-PTPRZ CA domain 13059 (VL+VH) synNotch | Expresses a synNotch receptor binding to PTPRZ |
| 247520 | pHR_PGK_ anti-PTPRZ CA domain 13059 (VH+VL) synNotch | Expresses a synNotch receptor binding to PTPRZ |
| 247521 | pHR_PGK_ anti-PTPRZ CA-FNIII domain 13062 (VL+VH) synNotch | Expresses a synNotch receptor binding to PTPRZ |
| 247522 | pHR_PGK_ anti-PTPRZ CA-FNIII domain 13062 (VH+VL) synNotch | Expresses a synNotch receptor binding to PTPRZ |
| 247523 | pHR_PGK_ anti-PTPRZ CA-FNIII domain 13069 (VL+VH) synNotch | Expresses a synNotch receptor binding to PTPRZ |
| 247524 | pHR_PGK_ anti-PTPRZ CA-FNIII domain 13069 (VH+VL) synNotch | Expresses a synNotch receptor binding to PTPRZ |
| 247525 | pHR_PGK_ anti-NRCAM 12949 (VL + VH) synNotch | Expresses a synNotch receptor binding to NRCAM |
| 247569 | pHR_PGK_ CSPG5 Neuroglycan 12960 VLVH synNotch | Expresses a synNotch receptor binding to CSPG5 Neuroglycan |
| 247570 | pHR_PGK_ BCAN 13134 VLVH synNotch | Expresses a synNotch receptor binding to BCAN |
| 247571 | pHR_PGK_ GRM3 13144 VLVH synNotch | Expresses a synNotch receptor binding to GRM3 |
| 247572 | pHR Gal4-UAS_3XFlag_4D5-5_CAR-mCherry_pGK_BFP | GAL4/UAS expression of a CAR against HER2 and mCherry with constitutive BFP |
| 247573 | pHR_PGK_ gb128_ BCAN 13138 VLVH synNotch | Expresses a synNotch receptor binding to BCAN |