Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells.
Shimazoe MA, Huertas J, Phillips C, Ide S, Tamura S, Farr S, Ashwin SS, Sasai M, Collepardo-Guevara R, Maeshima K
Sci Adv. 2026 Apr 10;12(15):eaec9801. doi: 10.1126/sciadv.aec9801. Epub 2026 Apr 8.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 247480 | pX330_H1.2 | Expresses SpCas9 and a sgRNA targeting the human histone H1.2 loci for knock-in. |
| 247481 | pGEM_H1.2_HaloTag | CRISPR/Cas9 donor plasmid to tag human histone H1.2 with Halo tag |
| 247482 | pX330_H1.0 | Expresses SpCas9 and a sgRNA targeting the human histone H1.0 loci for knock-in. |
| 247483 | pGEM_H1.0_HaloTag | CRISPR/Cas9 donor plasmid to tag human histone H1.0 with Halo tag |
| 247484 | pAAVS-NDi-H1.2_WT-Halo | Expresses H1.2 (WT) by tet-on system |
| 247485 | pAAVS-NDi-H1.2_Khalf-Halo | Expresses H1.2 (Khalf) by tet-on system |
| 247486 | pGEM_H1.2_mAID_mClover | CRISPR/Cas9 donor plasmid to tag human histone H1.2 with mAID-mClover |