SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss.
Xi X, Liu L, Tuano N, Tailhades J, Mouradov D, Steen J, Sieber O, Cryle M, Nguyen-Dumont T, Segelov E, Rosenbluh J
Proc Natl Acad Sci U S A. 2025 Apr 15;122(15):e2409677122. doi: 10.1073/pnas.2409677122. Epub 2025 Apr 10.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 233289 | inducible shSRP19_9 in pLKO tet on | Dox inducible expression of SRP19 shRNA |
| 233290 | SEAP (Protein secretion reporter) in pLX317 | SEAP reporter (used for monitoring protein secretion) |
| 233291 | SRP19 (siRNA resistant) in pLX311 | Expression of WT SRP19 (siRNA resistant) |
| 233292 | SRP19 in pLX311 | Expression of WT SRP19 |