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Multimodal control of Cas13 activity through domain insertion at an allosteric hotspot

Zhu L, Nguyen LT, Bell AG, Gillmann KM, Oatman H, Hariri J, Myhrvold C, Toettcher JE
bioRxiv 2025.04.21.649818 (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
248105LNPL503-piggybac-Dox-inducible-CasRx-QK634-LightR-IRES-mCherryExpresses dox-inducible OptoCas13d or CasRx-QK634-LightR (LightR domain inserted right after amino acid residue 634 of CasRx)
248111LNPL1093-piggybac-Dox-inducible-CasRx-QK634-UnirapR-IRES-mCherryExpresses dox-inducible ChemoCas13d or CasRx-QK634-LightR (UnirapR domain inserted right after amino acid residue 634 of CasRx)

Antibodies from Article