Synaptobrevin-2 disease variants reveal spatial constraints within the presynaptic active zone.
Guzikowski NJ, Bagatelas ED, Shin OH, Khan YA, Esquivies L, Alten B, Brunger AT, Kavalali ET
Proc Natl Acad Sci U S A. 2025 Nov 4;122(44):e2507347122. doi: 10.1073/pnas.2507347122. Epub 2025 Oct 30.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 248132 | pFUW-Syb2-A67P | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with A67P mutation |
| 248133 | pFUW-Syb2-E78A | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with E78A mutation |
| 248134 | pFUW-Syb2-F77S | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with F77S mutation |
| 248135 | pFUW-Syb2-G73W | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with G73W mutation |
| 248136 | pFUW-Syb2-R56L | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with R56L mutation |
| 248137 | pFUW-Syb2-R56X | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with R56X mutation |
| 248138 | pFUW-Syb2-S75P | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with S75P mutation |
| 248139 | pFUW-Syb2-V43del | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with V43del deletion |
| 248140 | pFUW-Syb2-I45del | Mammalian expression lentiviral vector encoding the wild-type Synaptobrevin2 (Syb2) with I45del deletion |