G(z)ESTY as an optimized cell-based assay for initial steps in GPCR deorphanization.
Franchini L, Porter JJ, Lueck JD, Orlandi C
Nat Commun. 2025 May 15;16(1):4521. doi: 10.1038/s41467-025-59850-8.
(Link opens in a new window)
PubMed
(Link opens in a new window)
Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 258850 | 4-in-1 D2R-GzESTY | Mammalian expression of the following 4 proteins: GsGz, PTX(S1), GloSensor-22F, and dopamine D2R. |
| 259905 | 2-in1 GzESTY | Mammalian expression of the following 2 proteins: GloSensor and PTX(S1) |
| 259906 | 3-in-1 GzESTY | Mammalian expression of the following 4 proteins: GsGz, PTX(S1), and GloSensor-22F. |
| 259907 | 4-in-1 MOR-GzESTY | Mammalian expression of the following 4 proteins: GsGz, PTX(S1), GloSensor-22F, and mu opioid receptor. |
| 259908 | 4-in-1 ADRA2A-GzESTY | Mammalian expression of the following 4 proteins: GsGz, PTX(S1), GloSensor-22F, and ADRA2AR. |
| 259909 | 5-in-1 GABAB-GzESTY | Mammalian expression of the following 5 proteins: GsGz, PTX(S1), GloSensor-22F, GABABR1 and GABABR2. |