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A chemical epigenetic tool to probe site-specific DNA-binding protein complexes.

Zhu J, Li Z, Xue D, Meng Z, Shao S, Pulecio J, Zhang G, Huangfu D, Evans T, Chen S, Schultz PG
Proc Natl Acad Sci U S A. 2025 Oct 7;122(40):e2509021122. doi: 10.1073/pnas.2509021122. Epub 2025 Oct 2. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
248695pAAVS1-P-6XPyltRNA-dCas9K1151TAG-IRESPylRSExpression dead CRISPR/Cas9 with unnatural amino acid incorporated at K1151 residue

Antibodies from Article