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Elevated SUN1 promotes migratory cell polarity defects through mechanically coupling microtubules to the nuclear lamina.

Li Y, Zhang Y, Chen M, Antoku S, Ding J, Huang K, Gundersen GG, Chang W
Commun Biol. 2025 Dec 9;9(1):9. doi: 10.1038/s42003-025-09229-8. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
248976pMSCV-puro-myc-S1-CC1-NP2Retroviral expression vector for myc-tagged mouse SUN1-SUN2 chimera protein (Nucleoplasmic region of SUN2 and coiled coil region and SUN domain of SUN1)
248977pMSCV-puro-myc-S1-CC2-NP2Retroviral expression vector for myc-tagged mouse SUN1-SUN2 chimera protein (Nucleoplasmic and coiled coil regions of SUN2 and SUN domain of SUN1)
248978pMSCV-puro-myc-S2-CC2-NP1Retroviral expression vector for myc-tagged mouse SUN1-SUN2 chimera protein (Nucleoplasmic region of SUN1 and coiled coil region and SUN domain of SUN2)
248979pMSCV-puro-myc-S2-CC1-NP1Retroviral expression vector for myc-tagged mouse SUN1-SUN2 chimera protein (Nucleoplasmic and coiled coil regions of SUN1 and SUN domain of SUN2)

Antibodies from Article