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Reconstitution of multistep recruitment of ULK1 to membranes in autophagy.

Duan Y, Lu Y, Paul S, Betz J, Wilhelm L, Cook ASI, Ren X, Adriaenssens E, Martens S, Ganley IG, Hummer G, Hurley JH
bioRxiv [Preprint]. 2025 Nov 9:2025.11.07.687251. doi: 10.1101/2025.11.07.687251. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
249533pCAG-TSF-ULK1Expressing human full length ULK1
249534pCAG-TSF-ULK1-ADAExpressing human full length ULK1 with P433A/V434D/P435A mutations
249535pBMN-HA-ATG13-HF|DDExpressing human full length ATG13 with H214D/F215D mutations
249729pCAG-MBP-ULK1-1-835-mcherryExpressing human ULK1-1-835 with a MBP tag in N-terminal and a mcherry tag in C-terminal
249732pCAG-MBP-ULK1-1-290-mcherrryExpressing human ULK1-1-290 with a MBP tag in N-terminal and a mcherry tag in C-terminal
249733pCAG-MBP-ULK1-290-835-mcherryExpressing human ULK1-290-835 with a MBP tag in N-terminal and a mcherry tag in C-terminal
250340pCAG-ATG101ΔCTHExpression human ATG101ΔCTH
250341pCAG-TSF-ATG101ΔCTH (WF|DD)Expressing human ATG101ΔCTH with W110D and F112D mutation
250342pCAG-GST-ATG101(WF|DD)Expressing human full length ATG101 with W110D and F112D mutations
250343pCAG-GFP-ATG13-1-230Expressing human ATG13 (aa. 1-230)
250344pCAG-GFP-ATG13-1-230(HF|DD)Expressing human ATG13 (1-230) with H214D/F215D mutations

Antibodies from Article