Dysregulation of FGFR1 signaling in the hippocampus facilitates depressive disorder.
Shin J, Oh H, Park JH, Bae H, Yang CM, Lee M, Kim S, Heo WD
Exp Mol Med. 2025 Aug;57(8):1818-1836. doi: 10.1038/s12276-025-01519-9. Epub 2025 Aug 15.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 250235 | AAV-hSyn-DIO-optoFGFR1-HA | Cre-dependent AAV expressing light-activatable FGFR1 (optoFGFR1-HA) for temporally precise control of neuronal FGFR1 signaling |
| 250236 | AAV-CaMKIIα-optoFGFR1-HA | AAV expressing light-activatable FGFR1 (optoFGFR1-HA) under the CaMKIIα promoter for excitatory-neuron-specific activation |
| 250237 | AAV-EF1α-DIO-DSE-mCherry-PSE-shRNA-Scramble | Cre-dependent AAV expressing mCherry and a scrambled shRNA under EF1α promoter. Used as a non-targeting control for shRNA knockdown |
| 250238 | AAV-EF1α-DIO-DSE-mCherry-PSE-shRNA-Numb | Cre-dependent AAV expressing mCherry and an shRNA targeting Numb under EF1α promoter for selective Numb knockdown |