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Alzheimer's disease-associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell-derived microglia-like cells.

Bedford LM, Tutrow KD, Hooper K, Messenger EJ, Hernandez M, Lamb BT, Meyer JS, Richardson TI, Bissel SJ
Alzheimers Dement. 2025 Oct;21(10):e70772. doi: 10.1002/alz.70772. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
254917PLCG2-M28LExpress PLCG2-M28L (disease variant) in human induced pluripotent stem cells.
254918PLCG2-P522RExpress PLCG2-P522R (protective variant) in human induced pluripotent stem cells.

Antibodies from Article