Coordinated regulation using small-molecule drugs enables controlled therapeutic genome editing and enhanced genomic precision in situ.
Zhang J, Chen L, Zhu X, Cai Y, Wei S, Zhou X, Shi Y, Liu C, Huang C, Bi S, Wu F, Zhou X, Hong J, Wang Y
Sci Transl Med. 2026 May 27;18(851):eadx7857. doi: 10.1126/scitranslmed.adx7857. Epub 2026 May 27.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 250956 | PRINCE-SpCas9-2 | PRINCE drug inducible gene editing system based on SpCas9 (Lentiviral-Part II: the sgRNA expression is under drug-mediated control) |
| 250957 | PRINCE-SaCas9-1 | PRINCE drug inducible gene editing system based on SaCas9 (AAV-Part I : the expression of SaCas9-NES) |
| 250958 | PRINCE-SaCas9-2 | PRINCE drug inducible gene editing system based on SaCas9 (AAV-Part II : the expression of 2x ERT2 and the sgRNA is under drug-mediated control) |
| 251232 | Little Prince-enOsCas12f1 | Drug inducible gene editing system based on enOsCas12f1 (Little Prince) |
| 251233 | Little Prince (TnpB) | Drug inducible gene editing system based on TnpB (Little Prince) |
| 251234 | Little Prince (enIscB) | Drug inducible gene editing system based on enIscB (Little Prince) |
| 251235 | PRINCE-SpCas9-1 | PRINCE drug inducible gene editing system based on SpCas9 (Lentiviral-Part II: the SpCas9 expression is under drug-mediated control) |