Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription.
Taghbalout A, Tung CH, Clow PA, Tjong H, Wang P, Wong CH, Mao DD, Maurya R, Huang MF, Ngan CY, Kim AH, Wei CL
Cancer Cell. 2025 Dec 8;43(12):2191-2205.e6. doi: 10.1016/j.ccell.2025.08.008. Epub 2025 Sep 18.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 251107 | pAT2732-(PB-4_EF1α-Hygro_2A_rtTA3 [HA-BFP-KRAB-PUFa]) | Expression of KRAB-PUFa component of Casilio-i system |
| 251108 | pAT1089-(PB-4_EF1α-Blast_2A_rtTA3 [HA-NLS-dCas9-NLS]) | Expression of dCas9 component of Casilio-i system |
| 251109 | pAT2977-(PB3-Puro-EGFP_7xU6-sgRNA-5xPBSa [MED1-Rank1_PC3 DM_AT_sg-213-219]) | Expression multiple sgRNAs |
| 251110 | pAT2978-(PB3-Puro-EGFP_7xU6-sgRNA-5xPBSa [MED1-Rank2_PC3 DM_AT_sg-234-240]) | Expression multiple sgRNAs |
| 251112 | pAT2982-(PB3-Puro-EGFP_7xU6-sgRNA-5xPBSa [MED1-Rank7_PC3 DM_AT_sg-241-247]) | Expression multiple sgRNAs |
| 251114 | pAT3157-{PB3-Puro-EGFP_7xU6-sgRNA-5xPBSa [MED1-Rank2_COLO320 DM_ AT_sg-283-289]) | Expression multiple sgRNAs |
| 251116 | pAT3159-(PB3-Puro-EGFP_7xU6-sgRNA-5xPBSa [MED1-Rank4_COLO320 DM_ AT_sg-297-303]) | Expression multiple sgRNAs |