PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration.
Ahmad S, Zou T, Hwang J, Zhao L, Wang X, Davydenko A, Buchumenski I, Zhuang P, Fishbein AR, Capcha-Rodriguez D, Orgel A, Levanon EY, Myong S, Chou J, Meyerson M, Hur S
Nat Commun. 2025 Apr 8;16(1):3325. doi: 10.1038/s41467-025-58433-x.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 251697 | PACT wild type | PRKRA protein expression construct in E. coli |
| 251699 | PACT deltaD2 | PRKRA (deletion of 110-198) protein expression construct in E. coli |
| 251700 | PACT deltaD3 | PRKRA (deletion of 197-313) protein expression construct in E. coli |