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Rational design of synthetic proteins using a genome-scale CRISPR screen

Burrell WH, Mueller SJ, Daniloski Z, Duffy Doyle Jr. P, Rovsing AB, James C, Drabkin M, Chou C-Y, So HYA, Katgara L, Sookdeo A, Lu L, Cisse G-I, Yan RE, Sanjana NE
bioRxiv 2026.02.19.706875 (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
251997pTE_01 - pLenti_EFS-Cas9-XTEN-ZRANB3-2A-BlastRLentiviral mammalian expression of Cas9-ZRANB3 TruEditor
251998pTE_02 - pLenti_EFS-Cas9-XTEN-FAN1-2A-BlastRLentiviral mammalian expression of Cas9-FAN1 TruEditor
251999pTE_03 - pLenti_EFS-Cas9-XTEN-BARD1-2A-BlastRLentiviral mammalian expression of Cas9-BARD1 TruEditor
252000pTE_04 - pLenti_EFS-Cas9-XTEN-ZNF146-2A-BlastRLentiviral mammalian expression of Cas9-ZNF146 TruEditor
252001pTE_05 - pLenti_EFS-Cas9-XTEN-SLX1A-2A-BlastRLentiviral mammalian expression of Cas9-SLX1A TruEditor
252002pTE_06 - pLenti_EFS-Cas9-XTEN-RAD18-2A-BlastRLentiviral mammalian expression of Cas9-RAD18 TruEditor
252003pTE_07 - pLenti_EFS-Cas9-XTEN-FEN1-2A-BlastRLentiviral mammalian expression of Cas9-FEN1 TruEditor
252004pTE_08 - pLenti_EFS-Cas9-XTEN-SPRTN-2A-BlastRLentiviral mammalian expression of Cas9-SPRTN TruEditor
252006pTE_10 - pCMV-Cas9_onlyMammalian expression of Cas9
252007pTE_11 - pCMV-Cas9-XTEN-BARD1Mammalian expression of Cas9-BARD1 TruEditor
252008pTE_12 - pCMV-Cas9-XTEN-SLX1AMammalian expression of Cas9-SLX1A TruEditor
252009pTE_13 - pCMV-Cas9-XTEN-FAN1Mammalian expression of Cas9-FAN1 TruEditor
252011pTE_15 - pCMV-Cas9-XTEN-ZRANB3Mammalian expression of Cas9-ZRANB3 TruEditor
252012pTE_16 - pLenti_EFS-Cas9-BLM(1-193)-2A-BlastRLentiviral mammalian expression of Cas9-BLM(2-194) TruEditor
252013pTE_17 - pLenti_EFS-Cas9-BARD1(32-117)-2A-BlastRLentiviral mammalian expression of Cas9-BARD1(32-117) TruEditor
252014pTE_18 - pCMV-Cas9-BLM(1-193)Mammalian expression of Cas9-BLM(2-194) TruEditor
252015pTE_19 - pIVT_CMV-synUTR-inactT7-NLS-Cas9-NLS-XTEN-NLS-HbaUTRIn vitro transcription of Cas9 only for mRNA generation
252016pTE_20 - pIVT_CMV-synUTR-inactT7-NLS-Cas9-NLS-XTEN-BARD1-NLS-HbaUTRIn vitro transcription of Cas9-BARD1 TruEditor for mRNA generation
252017pTE_21 - pIVT_CMV-synUTR-inactT7-NLS-Cas9-NLS-XTEN-BLM(1-193)-NLS-HbaUTRIn vitro transcription of Cas9-BLM(2-194) TruEditor for mRNA generation
252018pTE_22 - pIVT_CMV-synUTR-inactT7-NLS-Cas9-NLS-XTEN-SLX1A-NLS-HbaUTRIn vitro transcription of Cas9-SLX1A TruEditor for mRNA generation
252019pTE_23 - pDonor_TRAC-2a-FMC6.3-BBz-2aDonor for CD19 CAR knock-in at TRAC locus

Antibodies from Article