DOT1L provides transcriptional memory through PRC1.1 antagonism.
Neville D, Ferguson DT, Heikamp EB, Lai Z, Magor GW, Lam C, Dobbs OG, Levina V, Knezevic K, The JJ, Alex S, Suits SC, Rumler B, Uckelmann M, Talarmain L, Lam EYN, Perkins AC, Armstrong SA, Bell CC, Davidovich C, Gilan O
Nat Cell Biol. 2026 Feb 3. doi: 10.1038/s41556-025-01859-8.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 252955 | pET3_H3.1_C96S_C110A_K79C | Expression of human histone 3.1 mutant for generating lysine analogue H3.1_K79me2/3 |
| 252956 | pMB.PRC1.1_RING1B_MBP-PCGF1 | Expression of PRC1.1 core (RING1B and PCGF1) in insect cells. |
| 252957 | pMB.PRC1.4_RING1B_MBP-PCGF4 | Expression of PRC1.4 core (RING1B and PCGF4/BMI1) in insect cells. |