Design of soluble Notch agonists that drive T cell development and boost immunity.
Mout R, Jing R, Tanaka-Yano M, Egan ED, Eisenach H, Kononov MA, Windisch R, Najia MAT, Tompkins A, Hensch L, Bingham T, Gunage R, Zhao Y, Edman NI, Li C, Wang D, Schlaeger TM, Zon LI, North TE, Lendahl U, Rowe RG, Baker D, Blacklow SC, Daley GQ
Cell. 2025 Oct 16;188(21):5980-5994.e28. doi: 10.1016/j.cell.2025.07.009. Epub 2025 Aug 1.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 259187 | pET29b+_SpyCatcher_C5-15H | Bacterial expression of a pentameric, soluble Notch agonist C5 containing 15 helical arms (C5_15H) |