Inducible, split base editors for in vivo cancer functional genomics
Ren D, Wang S, Yamada K, Liu Y, Hapke R, Alpsoy A, Ho Y, Zhang C, Lan Y, Zhang S, Milazzo JP, Lohia R, Berríos KN, Li Y, Weber EW, Li Q, Vakoc CR, Minn AJ, Kohli RM, Shi J
Nat Biotechnol. 2026 Apr 15. doi: 10.1038/s41587-026-03077-5
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 253342 | Lenti-A3Ac-puro | Expresses the C-terminal fragment of a rapamycin-inducible split A3A cytosine base editor for in vivo base editing |
| 253343 | Lenti-A3An-LRG2.1T | Expresses the N-terminal fragment of a rapamycin-inducible split A3A cytosine base editor together with an sgRNA expression cassette for in vivo base editing |