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LDLR variant classification through activity-normalized prime editing screening.

Zhou PJ, Velimirovic M, Yu T, Gligorovski V, Mathis N, Zhao J, Phan QV, Vogd F, Ryu J, Pan Q, Tyagi A, Ascher DB, Schwank G, Pinello L, Cassa CA, Sherwood RI
bioRxiv [Preprint]. 2025 Dec 18:2025.12.16.694467. doi: 10.64898/2025.12.16.694467. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
254322lentiTet-LDLR-mCherryFus-S213L BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant S213L introduced in LDLR
254323lentiTet-LDLR-mCherryFus-G219D BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant G219D introduced in LDLR
254324lentiTet-LDLR-mCherryFus-K223E BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant K223E introduced in LDLR
254325lentiTet-LDLR-mCherryFus-D221Y BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant D221Y introduced in LDLR
254326lentiTet-LDLR-mCherryFus-D224H BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant D224H introduced in LDLR
254327lentiTet-LDLR-mCherryFus-S213L-G219D BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants S213L, G219D introduced in LDLR
254328lentiTet-LDLR-mCherryFus-G219D-K223E BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants G219D, K223E introduced in LDLR
254329lentiTet-LDLR-mCherryFus-K223E-S213L BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants K223E, S213L introduced in LDLR
254330lentiTet-LDLR-mCherryFus-S213L-G219D-K223E BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants S213L, G219D, K223E introduced in LDLR
254331lentiTet-LDLR-mCherryFus-E101K BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant E101K introduced in LDLR
254332lentiTet-LDLR-mCherryFus-E240K BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant E240K introduced in LDLR
254333lentiTet-LDLR-mCherryFus-D221G BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant D221G introduced in LDLR
254334lentiTet-LDLR-mCherryFus-D227E BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variant D227E introduced in LDLR
254335lentiTet-LDLR-mCherryFus-G219D-E101K BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants G219D, E101K introduced in LDLR
254336lentiTet-LDLR-mCherryFus-S213L-G219D-K223E-E101K BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants S213L, G219D, K223E, E101K introduced in LDLR
254337lentiTet-LDLR-mCherryFus-G219D-E240K BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants G219D, E240K introduced in LDLR
254338lentiTet-LDLR-mCherryFus-S213L-G219D-K223E-E240K BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants S213L, G219D, K223E, E240K introduced in LDLR
254339lentiTet-LDLR-mCherryFus-G219D-D221G BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants G219D, D221G introduced in LDLR
254340lentiTet-LDLR-mCherryFus-S213L-G219D-D221G BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants S213L, G219D, D221G introduced in LDLR
254341lentiTet-LDLR-mCherryFus-G219D-D227E BlastRDox inducible LDLR coding sequence expression construct cloned into a lentiviral backbone containing a blasticidin resistance gene, variants G219D, D227E introduced in LDLR

Antibodies from Article