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A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution.

Špokaitė S, Ohashi Y, Bourguet M, Dessus AN, Williams RL
eLife (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
235711pYO1344Expression of FL human VPS34 R199E E200R E202R mutant in mammalian cells
235713pYO1356Expression of FL human VPS34 R199E E200R E202R muntant-EGFP in mammalian cells
235714pYO1846Expression of mCherry-human Beclin 1 in mammalian cells
235715pYO1847Expression of FL human VPS15 S579D_H580D_T583E mutant -ZZ in mammalian cells
235716pYO1865Expression of FL human VPS15 S579D_H580D_T583E mutant in mammalian cells
235720pYO634Expression of FL yeast VPS15-EGFP under its own promoter in yeast
235721pYO1880Expression of FL yeast VPS15 S622D_H623D_T626E mutant -EGFP under its own promoter in yeast
235722pYO950Expression of FL yeast VPS15-3x FLAG under its own promoter in yeast
235723pYO1877Expression of FL yeast VPS15 S622D_H623D_T626E mutant-3x FLAG under its own promoter in yeast
235739pYO1510Protein expression of mCherry-14 x His in bacteria
235767pYO1920Protein expression of ScVPS34 untagged + ScVPS15 S622D_H623E_T626E-ZZ in yeast
235768pYO1922Protein expression of ScVPS38+ScVPS30-mCherry
235769pYO1919Protein expression of 6xHis ScVPS21 (Q66L)-EGFP
242480pYO1879Integrate dRFP-ScVPS21 Q66L into the yeast genome with LEU2 marker

Antibodies from Article