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Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4.

Dhar SS, Lee SH, Kan PY, Voigt P, Ma L, Shi X, Reinberg D, Lee MG
Genes Dev. 2012 Dec 15;26(24):2749-62. doi: 10.1101/gad.203356.112. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
255997pFLAG-CMV2-MLL4fusionThis plasmid expresses a mini-version of human MLL4 (aka KMT2D), which is composed of a tandem PHD (PHD4-6;1358–1572aa) and a SET (catalytic domain)-containing C-terminal region (4507–5537aa).
256014pFLAG-CMV2-mMLL4fusionThis plasmid expresses a mutant mini-version of human MLL4 (KMT2D) composed of a mutant PHD4-6 (1358–1572aa) bearing E1516A/E1517A/D1518A/E1544A and a SET-containing C-terminal region (4507–5537aa).

Antibodies from Article