Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator.
Wu Y, Hao C, Gao C, Hageman M, Lee S, Kirkland TA, Gray NS, Su Y, Lin MZ
Nat Chem Biol. 2025 Aug;21(8):1194-1204. doi: 10.1038/s41589-025-01846-y. Epub 2025 Feb 11.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 256282 | pAAV-CMV-caAkt-P2A-AktKiMBI | Expresses Akt KiMBI to report Akt inhibition with bioluminescence, with caAkt to increase basal Akt activity, and can be packaged into AAV particles |
| 256283 | pAAV-CMV-caAkt-P2A-AktKiMBImut | Non-responsive mutant control for Akt KiMBI |