Biosensor-guided evolution of chalcone synthase enhances biosynthesis of natural and non-natural flavanones.

Hanko EKR, Kesornpun C, Whitehead JN, Spiess R, Robinson CJ, Scrutton NS
Metab Eng. 2026 Oct 7:102564. doi: 10.1016/j.ymben.2026.102564. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
258001	SBC016302	Expression of Glycine max 4CL4, Arabidopsis thaliana CHS and CHI2, together with an FdeR‑based biosensor, for the production and detection of flavanones.
258002	SBC016397	Expression of Glycine max 4CL1, Arabidopsis thaliana CHS and CHI2, together with an FdeR‑based biosensor, for the production and detection of flavanones.
258003	SBC016420	Expression of Glycine max 4CL1, Hordeum vulgare CHS2, and Arabidopsis thaliana CHI2, together with an FdeR‑based biosensor, for the production and detection of flavanones.
258004	SBC016421	Expression of Glycine max 4CL1, Hordeum vulgare CHS2, and Medicago sativa CHI1, together with an FdeR‑based biosensor, for the production and detection of flavanones.
258005	SBC016434	Expression of Glycine max 4CL1, Arabidopsis thaliana CHS, and Medicago sativa CHI1, together with an FdeR‑based biosensor, for the production and detection of flavanones.
258007	SBC016441	Expression of Glycine max 4CL4, Hordeum vulgare CHS2, and Arabidopsis thaliana CHI2, together with an FdeR‑based biosensor, for the production and detection of flavanones.
258008	SBC016442	Expression of Glycine max 4CL4, Hordeum vulgare CHS2, and Medicago sativa CHI1, together with an FdeR‑based biosensor, for the production and detection of flavanones.
258009	SBC016443	Expression of Glycine max 4CL4, Arabidopsis thaliana CHS, and Medicago sativa CHI1, together with an FdeR‑based biosensor, for the production and detection of flavanones.