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Traceless protein semisynthesis in cells using the promiscuous ultra-fast split intein NrdJ-1.

Ye X, Sokol J, Kofoed C, Dheer A, Zhang J, Muir TW
Chem Sci. 2026 Apr 28. doi: 10.1039/d6sc01808d. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
258592pET-His-SUMO-HA-MBP-NrdJ-1NExpression of His-SUMO tagged HA-MBP-NrdJ-1 N intein in bacteria for protein splicing. NGTNPC as N-extein.
258597pET-His-SUMO-NrdJ-1N (C76A)Expression of His-SUMO tagged NrdJ-1 N intein in bacteria for protein semi-synthesis and splicing, with C76A mutation

Antibodies from Article